Principal Scientist, Translational Research - Translational Safety Strategy

Bristol Myers Squibb • Seattle, WA

20h • Onsite

About The Position

The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes. Position Summary: We are seeking a highly skilled, collaborative, and detail-oriented scientist to join our Translational Research team, bringing deep expertise in CAR T cell therapy and a rigorous scientific foundation in immunology, molecular/cell biology, and/or virology. In this role, you will serve as a Translational Safety Strategy Lead, driving the evaluation of gene-modified CAR T cell product-related genotoxicity in alignment with established study protocols and applicable regulatory guidelines. Your work will span early- and late-stage clinical programs, with particular emphasis on post-marketing settings, ensuring robust and consistent translational safety oversight across a diverse CAR T portfolio.

Requirements

• Bachelor’s Degree 8+ years of academic and / or industry experience Or Master’s Degree 6+ years of academic and / or industry experience Or Ph.D. or equivalent advanced degree in Life Sciences 4+ of academic and / or industry experience

Nice To Haves

• Ph.D. with 7+ years of combined experience in clinical trial research and basic sciences, including industry and/or biotech settings, with strong background in cell therapy, immunology, molecular/cell biology, and/or virology.
• Exceptional scientific communication and writing skills, with demonstrated track record in manuscript writing and proven ability to collaborate effectively across cross-functional teams in a fast-paced, highly matrixed environment while managing completing priorities and tight timelines.
• Strong working knowledge of regulatory frameworks and requirements, including hands-on experience drafting and reviewing regulatory documents, supporting regulatory inquiries and submissions, and contributing to translational strategy development.

Responsibilities

• Lead end-to-end translational safety strategies, testing, and reporting across multiple assets and platforms, spanning clinical and commercial programs, ensuring critical alignment with research, clinical development, and medical affair objectives.
• Oversee complex testing operations, including sample testing workflows, case tracking, data flow, and data management operations; lead in-depth complex case investigations across clinical and commercial settings with scientific rigor and operational precision.
• Drive continuous process improvements, streamlining data reporting flows and optimizing testing workflows, assay services, and data reporting infrastructure; drive cross-functional efficiency through proactive operational dialogue and stakeholder engagement.
• Provide scientific leadership and interpretation, integrating translational safety data to inform critical clinical and regulatory decision-making; serve as a subject matter expert contributing scientific insights to health authority inquiries and regulatory submissions.
• Operate effectively in a fast-paced, highly matrixed environment, setting priorities with clarity, confidence, and adaptability, cultivating a collaborative and inclusive team culture, and building and sustaining strategic partnerships both internally and externally.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree