Principal Scientist - Toxicology

AbCellera•Vancouver, BC

21h•CA$134,000 - CA$168,000•Onsite

About The Position

We are looking for an experienced, strategically minded Principal Scientist to join our expanding Non-Clinical Safety team based in Vancouver, Canada. You will be responsible for designing, planning, monitoring, and reporting of non-GLP and GLP toxicology studies and provide nonclinical safety support for early to late stage programs.

Requirements

Deep expertise in GLP-compliant nonclinical toxicology, including hands-on experience with US FDA 21 CFR Part 58, and a strong working knowledge of FDA, ICH, and EMA nonclinical regulatory guidance
Proven track record of designing, overseeing, and interpreting non-GLP and GLP toxicology studies in support of discovery and development programs
PhD in Toxicology or a related field, with 8+ years of relevant industry experience supporting biologics development; candidates with a MSc degree and 12+ years of directly applicable experience will also be considered
Ability to lead scientific discussions and influence decision-making within highly matrixed, cross-functional teams through clear, confident, and effective communication
Excellent scientific writing skills, with experience authoring and reviewing toxicology reports and regulatory submission documents
Strong organizational and prioritization skills, enabling effective management of multiple programs and timelines in a fast-paced environment
Sound scientific judgment and critical problem-solving skills to assess complex datasets, identify risks, and propose strategic solutions
Thrive in a dynamic, evolving environment, demonstrating flexibility, resilience, and a proactive approach to change

Nice To Haves

Experience with oncology and/or ADC programs is highly desirable
DABT accreditation

Responsibilities

Leading the planning, design, execution and interpretation of nonclinical toxicology programs in support of IND, CTA and BLA submissions, including general toxicity and reproductive and developmental toxicology studies, in alignment with global regulatory expectations and program strategy
Serving as the primary scientific interface with contract research organizations (CROs), providing strategic oversight during protocol development, study conduct, data interpretation, and report finalization to ensure timely, high-quality, and GLP-compliant delivery of nonclinical studies
Representing the Nonclinical Safety function as a core member of cross-functional discovery and development program teams, contributing toxicology expertise to inform candidate selection, risk assessment, and overall program advancement
Providing critical scientific assessment of toxicology data and communicating clear, actionable risk-benefit evaluations and recommendations to project teams and senior leadership, including potential implications for clinical development and regulatory strategy
Authoring and reviewing nonclinical safety sections of regulatory documents (INDs, CTAs, IBs, and BLAs), and contributing as a subject matter expert to global regulatory interactions and health authority responses
Driving the development and evolution of integrated nonclinical safety strategies across AbCellera’s therapeutic portfolio, ensuring consistency, scientific rigor, and alignment with company objectives
Maintaining scientific leadership by staying current with advances in toxicology science, methodologies, and evolving regulatory guidance, and proactively translating these insights into best practices for internal programs