Principal Scientist, Research (Targeted Delivery)

Alnylam Pharmaceuticals•,

1d•$147,200 - $220,800•Onsite

About The Position

The Research Department at Alnylam is seeking a Principal Scientist to join a growing team responsible for advancing RNAi therapeutics into the future, by opening up targeted delivery to all tissues. The successful candidate will be a key leader in our ligand discovery efforts, responsible for driving end-to-end ligand discovery projects for novel receptors. This role requires a deep understanding of antigen design, antibody engineering, immunology, and high-throughput screening technologies. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

PhD in Molecular Biology, Bioengineering, Biochemistry, Cell Biology, or a related field.
A minimum of 6 years of post-PhD experience in the biopharmaceutical industry, with a primary focus on antibody discovery and engineering.
Proven track record of successfully leading antibody discovery programs from inception to lead candidate delivery.
Hands-on experience with single B cell isolation and screening technologies is required; direct experience with the Bruker Beacon platform is required.
Deep expertise in molecular biology techniques for antibody cloning, expression, and sequence analysis, including extensive experience with NGS library preparation and data interpretation.
Demonstrated experience developing and running high-throughput, automated screening assays.
Experience with managing external research collaborations and CROs for immunization and discovery campaigns.

Nice To Haves

Track record of successfully managing and developing research scientists preferred

Responsibilities

Lead the design and implement innovative immunization strategies, including the identification, selection, and management of external immunization vendors (CROs).
Establish and oversee high-throughput B cell screening and selection workflows.
Develop and integrate a robust Next-Generation Sequencing (NGS) workflow for the rapid identification and analysis of antibody variable region sequences from screening campaigns.
Drive the design, execution, and automation of high-throughput screening cascades to characterize antibody properties such as affinity, specificity, and function.
Engineer complex antibody modalities, including Mult specific antibodies, nanobodies, and evaluate novel protein formats.
Collaborate with cross-functional teams, including protein science, pharmacology, and translational science to ensure project goals are achieved.
Manage project timelines, resources, and data analysis, and present findings to internal teams and senior leadership.