Principal Scientist, Protein Biochemistry and Structural Biology

Terray Therapeutics • Monrovia, CA

5d • $180,000 - $263,000 • Onsite

About The Position

Terray Therapeutics is seeking a creative and experienced structural biologist/protein biochemist. This role will be full-time onsite. As a resident expert, the candidate will be expected to work across multidisciplinary teams to generate constructs and lead protein purification efforts that will support assay design and screening needs. Furthermore, the candidate will be expected to utilize structural biology to support target validation and optimization of small molecule hits from Terray’s proprietary EMMI platform. Successful candidate will have strong protein biochemistry/structural biology experience and understanding of strategic application of structural biology in drug discovery programs with demonstrated experience in utilizing proteins design that matches program needs.

Requirements

• PhD in either Structural Biology, Biochemistry, Biophysics or related field and at least 10 years of additional experience
• Extensive experience in protein purification. Ideal candidate will have experience in construct design, expression and protein purification in multiple systems (E. coli, Insect, Mammalian) and have investigated broad range of protein families
• Experience in leveraging structural biology and protein structure/function to evaluate novel drug targets and small molecule binding
• Ability to work in multidisciplinary, matrixed environment across multiple concurrent projects and programs
• Excellent organizational, communication and interpersonal skills

Nice To Haves

• Ideal candidate will have hands-on experience in Structural Biology. Preferably, they would have used X-ray crystallography and/or Cryo-EM and accompanying software to investigate, analyze and assess small molecule binding to target of interest

Responsibilities

• Leverage structural biology expertise to guide protein construct design and purification strategy across programs as well as assess current and future crystallography needs to enable programs or validate targets
• Partner closely with scientists across the company in biology, chemistry, platform, screening, data, and computational teams to understand and provide correct implementation of the constructs and purified proteins.
• Manage relationships and partnership protein needs across network of CROs
• Guide protein quality control and stability investigation of purified protein material to ensure consistence across assays and platform data
• Build effective protein management and protein organization workflow
• Maintain and manage protein inventory, registration within Benchling
• Apply effective protein design toward assay development (biochemistry vs biophysical assays)

Benefits

• participation in the Company’s stock option plan
• a 3% retirement safe harbor contribution
• fully paid health, dental, vision insurance for our employees, spouse, partner and families
• above-market life insurance
• disability coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree