Principal Scientist, Process Chemistry
About The Position
Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes.
Requirements
- PhD in Organic Chemistry or related field with 8+ years of relevant industrial experience in process chemistry
- Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals
- Demonstrated success in developing scalable synthetic processes
- Proficiency with standard analytical instruments and data interpretation
- Excellent problem-solving, organization, and communication skills
- Ability to work independently while contributing effectively to a team environment
- Familiarity with cGMP and ICH guidelines
- Strong attention to detail and a commitment to high-quality experimentation
- Ability to manage multiple projects and shifting priorities
- A proactive, collaborative mindset with enthusiasm for process improvement
- Must be willing to work onsite 5 days a week
Responsibilities
- Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
- Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
- Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques
- Perform impurity identification and synthesis
- Identify and mitigate process risks related to safety, scalability, and robustness
- Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance
- Prepare clear, data-driven reports and present experimental results to project teams
- Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
- Maintain accurate lab documentation and adhere to all safety and compliance standards
Benefits
- Two annual cash bonuses
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
