Principal Scientist, Oncology Drug Discovery
About The Position
The Intracellular Targeted Cancer Therapeutics (ITCT) Biology Unit within GSK’s Oncology Research Unit is seeking an experienced cancer biologist for an Investigator role supporting a growing portfolio of precision oncology assets. The role provides basic and translational biology support for target validation, drug discovery, and early clinical development of novel small-molecule cancer therapies. The successful candidate will have experience designing and executing biological studies to understand the mechanisms of action of small-molecule cancer therapeutics. This scientist will work independently and within a dynamic global matrix team to design, execute, or oversee impactful in vitro experiments. The role also involves championing innovative experimental techniques and technologies, building communication networks across the Oncology Research Unit and broader organization, and guiding the maturation and de-risking of novel therapeutic concepts. The position is based on-site in either Cambridge, Massachusetts, or Upper Providence, Pennsylvania. Hybrid and remote work options are not available.
Requirements
- BS in Cell, Molecular, or Cancer Biology, Pharmacology, or a related life sciences field and at least 5 years of relevant industry experience; or MS in a related field and at least 3 years of relevant industry experience; or PhD in a related field and 0 years of relevant industry experience.
- At least 3 years of experience designing, executing, and analyzing cellular and molecular biology experiments using small-molecule therapeutics and a diverse array of current scientific techniques.
Nice To Haves
- At least 2 years of drug discovery experience in a biotech, preclinical CRO, or pharmaceutical company.
- Deep knowledge of molecular oncogenesis, signaling pathways, and bivalent or molecular glue modalities.
- Deep expertise in assay development in a drug discovery setting.
- Experience applying genomic editing techniques to dissect target biology and drug mechanisms.
- A proven record of scientific expertise and achievement in cell biology and cancer biology through peer-reviewed publications.
- Working knowledge of omics methods such as sequencing, transcriptomics, and/or proteomics, and databases such as TCGA, CCLE, and DepMap.
- Attention to detail and proficient reasoning in experimental design, data analysis, statistical methods, and interpretation.
- Independence, problem-solving ability, self-motivation, resourcefulness, organizational, interpersonal, and communication skills, and the ability to work efficiently in a fast-paced team environment.
Responsibilities
- Provide basic and translational biology support for target validation, drug discovery, and early clinical development of novel small-molecule cancer therapies within a dynamic global matrix team.
- Independently design, execute, and/or oversee impactful in vitro experiments to inform development of portfolio assets.
- Champion innovative experimental techniques and technologies, including medium-throughput scalable assay development, target-specific mechanistic biology, and monotherapy and combination anticancer efficacy testing of assets.
- Build communication networks across the Oncology Research Unit and the broader organization.
- Guide the maturation and de-risking of novel therapeutic concepts.
Benefits
- Competitive salary
- Annual bonus based on company performance
- Healthcare and wellbeing programs
- Pension plan membership
- Shares and savings programme
- Share-based long-term incentive program eligibility, dependent on role level
- Health care and other insurance benefits for employees and family
- Retirement benefits
- Paid holidays
- Vacation
- Paid caregiver, parental, and medical leave
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What This Job Offers
Job Type
Full-time
Career Level
Principal
