Principal Scientist - Modeling & Simulation
About The Position
Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist - Modeling & Simulation. What you will do. Let’s do this. Let’s change the world. In this vital role you will support Amgen clinical development and translational sciences programs across multiple therapeutic areas as part of the Clinical Pharmacology, Modeling and Simulation department.
Requirements
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
- Master’s degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
- Bachelor’s degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience
Nice To Haves
- PhD in pharmaceutical sciences, applied statistics/mathematics, bio-statistics, and/or engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3 years of PK/PD or statistical modeling experience
- 5 + years industry or relevant academic experience in pharmacometric analyses and/or applied bio-statistics of small molecules and/or biologics.
- Proficiency in modeling software (e. g. NONMEM, SAS, R/S-Plus, STAN, MATLAB
Responsibilities
- Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.
- Conducting binary and categorical and binary data analyses, time-to-event (hazard) models, Poisson models, MCMC and Bayesian methods as applied to exposure-response analyses and Population PK and PKPD analysis.
- Performing meta-analysis using proprietary and/or literature data.
- Participating in cross-functional project teams and providing scientific input for dose selection, early and late study designs using modeling and simulation inputs.
- Contributing to clinical pharmacology strategy for the program(s) and implementing project plans.
- Generating modeling reports and contributing to the summary documents for regulatory submissions.
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
