Principal Scientist, Machine Learning - Biomolecules

Flagship Pioneering•Cambridge, MA

16h•Hybrid

About The Position

Pioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. The role involves leading multiple AI/ML or computational projects across early stage ventures, as a part of Flagship’s company origination process. The scientist will define and deliver pragmatic AI strategies, oversee method and platform development (e.g., systems design, drug design, molecular modeling, systems biology, protein design, LLM/agentic workflows), and ensure rigor in model development, benchmarking, scaling, and reporting. Management of cross-functional contributors, influencing company direction, and representing PI to venture teams and external partners are also key aspects of this role. The ideal candidate is a self-directed serial deep diver who can adapt to diverse scientific domains and automate scientific workflows using LLM-based agents.

Requirements

Master’s, or PhD in a relevant field (e.g., machine learning, mathematics, statistics, computational sciences) with 5+ years' experience scientific/engineering/computational in academic, pharmaceutical, or biotechnology settings; industry AI/ML experience preferred.
Experience driving results directly or indirectly through teams of engineers/scientists in dynamic, fastpaced, entrepreneurial, and technical environments.
Clear evidence of sustained independent thought and creativity driving high impact, cross disciplinary AI/ML projects.
Successful track record of leadership and contribution to decision making on progression of AI/ML models within projects or programs.
Depth across multiple core tools and concepts, including Python; modern ML frameworks (PyTorch or JAX/TensorFlow); version control; databases; deep learning architectures; and relevant informatics software.
Consistent record of outstanding performance reflected in publications, patents, or high impact internal reports where applicable.

Nice To Haves

Breadth across domains such as protein modeling/design, proteomics/mass spec, cheminformatics/docking/ADMET, biophysics/MD, and LLM/agentic automation.
MLOps expertise: data contracts and lineage (e.g., DVC/LakeFS), experiment tracking (MLflow/W&B), secure AWS infrastructure (S3, Batch/ECS/EKS, SageMaker), Docker, IaC (Terraform/CDK), and CI/CD (GitHub Actions).
Generative modeling (diffusion/flow/VAEs) for sequences, graphs, or 3D structures; docking rescoring (e.g., gnina, DiffDock) and pose quality metrics.
Workflow orchestration (Airflow/Prefect/Argo), data warehouses (Redshift/Snowflake), vector search (FAISS/pgvector), and lightweight internal tools (FastAPI, Streamlit/Gradio).
Experience mentoring early hires, acting as interim Head of ML, and contributing to hiring plans and interview processes at startups.

Responsibilities

Lead development, implementation, control, and reporting of several AI/ML or computational projects within assigned ventures in line with broader strategic plans of PI and Flagship, budgets, and timelines.
Take a specialized technical role on project teams to oversee method development, pipeline development, and LLM based agent/workflow design; drive benchmarking, scaling, and implementation into production grade systems.
Promote operational excellence in AI projects by educating cross-functional collaborators.
Manage and/or coordinate internal and external scientists/engineers and crossfunctional project teams as applicable; mentor early hires; support recruiting and interview.
Contribute to project planning, including budgets, resources, and timelines; surface risks and tradeoffs early with clear options.
Independently scout emerging literature and the AI/ML landscape; synthesize concepts to propose new development strategies and identify opportunities for PI and venture portfolios.
Represent PI to portfolio companies and external partners; act as a recognized subject matter expert; actively participate in scientific conferences and meetings.
Influence the course of projects and technical approaches; adapt and present complex findings to diverse audiences to support meaningful interpretation and action.