Principal Scientist - In Vivo Expert, CVRI (Cardiovascular, Renal & Immunology)

Bayer•Cambridge, MA

19d•$139,840 - $209,760•Onsite

About The Position

Bayer has an opening for a Principal Scientist to join our Cardiovascular-Renal In Vitro Research group based at the Bayer Innovation Campus at the heart of Kendall Square in Cambridge, MA, with the goal to enhance internal expertise in the heart and kidney in vivo biology space. We are looking for a scientist with significant hands-on expertise in utilizing mechanistic and disease renal and cardiac in vivo models to enable the characterization of novel drug targets or therapeutic molecules. Specifically, the candidate will design and conduct experimental research studies at the bench, coach research associates, and propose therapeutics project(s) targeting cardiac or renal (including cardio-renal metabolic) disease. This is an excellent opportunity for a highly motivated candidate interested in exploring the early stages of drug development in a vibrant and collaborative atmosphere.

Requirements

A Ph.D. in Biology (Cellular, Molecular or Developmental Biology), Biochemistry, or related life science field
A background in cardiorenal disease biology would be highly advantageous
In depth expertise and hands-on experience in mechanistic and disease renal and cardiac in vivo models and its translation to cardiovascular or renal disease modeling and drug discovery
Hands-on experience in setting up and characterizing in vivo renal and cardiac rodent models for disease modeling and profiling of drug candidates
Strong expertise in clinically relevant readouts (including imaging, hemodynamics, and biomarker) to characterize in vivo models
Track record of working on complex problems, and ability to integrate data from multiple disciplines
Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
Must demonstrate outstanding personal initiative, and accountability, communication skills, and the ability to work effectively as part of a team
Ability to adapt, prioritize activities to and effectively manage changes in a fast paced and dynamic environment
A passion for science and sense of urgency to find new medicines to benefit patients

Nice To Haves

8+ years of relevant post-PhD experience including 4+ years in industry is preferred, with a proven record of successful team leadership and interaction with collaborators

Responsibilities

Responsible for identifying and setting up relevant mechanistic and disease in vivo models to support cardiovascular and renal projects from target identification to preclinical candidate acceptance and early clinical development including hands-on experimentation, analysis of data and presentation to cross-functional project teams
Prepare and update experimental protocols
Independently perform data analysis and effectively interpret results
Support evaluation of external innovation landscape in the field of in vivo models and connection to external partners (CROs, academic partners)
Lead novel target proposals and experimental validation to support growth of our early cardiovascular & renal portfolio including presentation at internal governance
Support BD&L assessment of external targets and programs to understand the competitive landscape and identify potential opportunities for collaboration or technological innovation
Engage in close collaboration with scientists and technical staff of the In Vivo Cluster based at the German sites to share knowledge, drive progress and stimulate innovation
Lead publication of results, prepare reports and presentations at both internal and external forums
Coach research associates in a matrix organization
Collaborate effectively with colleagues and interdisciplinary teams both within Bayer and with external collaborators
Ensure that all tasks are aligned with respect to HSE guidelines, animal welfare law and regulations, documentation guidelines, and good research practices