Principal Scientist, Immunopeptidomics

Johnson & Johnson Innovative Medicine•Cambridge, MA

10d•$117,000 - $201,250•Onsite

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biological Research Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine We are searching for the best talent for a Principal Scientist, Immunopeptidomics to be located in Cambridge, MA. Purpose: Do you want to use your hard‑earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high‑scale proteomic analysis! Be part of a motivated team deploying innovative mass spectrometry technologies to tackle challenges in end‑to‑end drug discovery and development across a leading multiomics organization. We work shoulder‑to‑shoulder across biology, chemistry, and data science to deliver clear, reproducible proteomic readouts that move medicines forward. With your help, we will drive development of medicines for our patients! Lead the development and delivery of immunogenicity assays supporting discovery programs across the Innovative Medicine portfolio. You will focus on hands‑on assay development, high‑throughput screening, and data generation, while working closely with diverse teams of protein engineers, data scientists, and biologists. You will be responsible for: Leading must-win immunogenicity projects across biologics, CAR-T, and peptide therapeutics from early discovery through candidate selection. Owning the design, implementation, and execution of novel high throughput assays; continuously improving. methods and workflows to enhance efficiency and quality. Translating assay results into clear, decision-enabling interpretations for program and engineering teams. Ensuring strong data integrity, documentation, and reproducibility. Driving rapid innovation and providing technical leadership, while building strong multi-functional relationships as a scientific partner. Developing and operationalizing population-aware immunogenicity risk assessment strategies, ensuring consistent application across programs and integration within discovery and engineering cycles.

Requirements

PhD in Immunology, Biochemistry, Cellular/Molecular Biology, Bioengineering or a related field is required.
6+ years of proven biotech or pharmaceutical experience is required.
Demonstrated expertise in immunology with hands-on experience developing, implementing, and interpreting complex immune cell-based assays is required.
Strong cross-functional communication skills with the ability to translate multi-dimensional datasets into a decision-relevant narrative is required.

Nice To Haves

Hands on experience with LC-MS instrumentation in support of immunopeptidomics workflows is preferred.
Experience developing high-throughput assay workflows from pilot to scalable routine deployment is preferred.
Hands-on experience with integrated lab automation systems is preferred.
Familiarity with therapeutic engineering concepts is desirable.
Experience working with in silico tools and integrating computational outputs with experimental data is preferred.

Responsibilities

Lead the development and delivery of immunogenicity assays supporting discovery programs across the Innovative Medicine portfolio.
Focus on hands-on assay development, high-throughput screening, and data generation, while working closely with diverse teams of protein engineers, data scientists, and biologists.
Lead must-win immunogenicity projects across biologics, CAR-T, and peptide therapeutics from early discovery through candidate selection.
Own the design, implementation, and execution of novel high throughput assays; continuously improving methods and workflows to enhance efficiency and quality.
Translate assay results into clear, decision-enabling interpretations for program and engineering teams.
Ensure strong data integrity, documentation, and reproducibility.
Drive rapid innovation and provide technical leadership, while building strong multi-functional relationships as a scientific partner.
Develop and operationalize population-aware immunogenicity risk assessment strategies, ensuring consistent application across programs and integration within discovery and engineering cycles.

Benefits

medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
consolidated retirement plan (pension) and savings plan (401(k)).
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
Caregiver Leave – 10 days
Volunteer Leave – 4 days
Military Spouse Time-Off – 80 hours