Principal Scientist II
About The Position
We are seeking a highly motivated Principal Scientist to join our xDC team and help advance next-generation targeted therapeutic platforms. This role will contribute to the development and expansion of biologics and drug-conjugate infrastructure, with a focus on innovative vectorization strategies, biology-informed payload approaches, and differentiated conjugate designs. The ideal candidate will bring strong scientific judgment, hands-on technical expertise, and experience working in a collaborative, cross-functional environment. Industry experience in biologics, ADCs, targeted therapeutics, or related modalities is preferred.
Requirements
- Ph.D. in biology, biochemistry, molecular biology, pharmacology, immunology, chemical biology, bioengineering, or a related discipline
- 3–5 years of relevant post-Ph.D. experience, preferably in an industry setting
- Experience with biologics, antibody-drug conjugates, targeted delivery platforms, protein therapeutics, or related modalities
- Strong understanding of disease biology, target selection, mechanism-of-action studies, and translational research principles
- Demonstrated ability to design rigorous experiments, analyze complex data, and make data-driven recommendations
- Strong communication, collaboration, and problem-solving skills
- Ability to work effectively in a fast-paced, multidisciplinary research environment
Nice To Haves
- Industry experience in biologics, ADCs, targeted therapeutics, or related modalities is preferred.
- Familiarity with biologics engineering, conjugation strategies, payload biology, or preclinical therapeutic development is preferred
- Prior experience in ADC, xDC, or other targeted therapeutic platforms
- Experience evaluating novel targets, payload mechanisms, or biology-driven therapeutic hypotheses
- Familiarity with in vitro and in vivo pharmacology workflows
- Experience working with external partners, CROs, academic collaborators, or technology vendors
- Track record of scientific contributions through publications, patents, presentations, or program advancement
Responsibilities
- Drive scientific activities supporting the discovery and optimization of next-generation xDC and biologics platforms
- Contribute to the design and evaluation of new vectorization approaches for targeted delivery
- Support the development of payload strategies aligned with disease biology and therapeutic mechanism of action
- Participate in the exploration of differentiated conjugate formats, including multi-payload or combination-based approaches
- Work closely with cross-functional teams across biology, chemistry, protein engineering, pharmacology, translational sciences, and CMC
- Design, execute, and interpret experiments to guide platform and program decisions.
- Identify emerging scientific opportunities and help translate them into actionable research strategies
- Communicate results clearly through presentations, reports, and scientific discussions
- Contribute to external collaborations and technology evaluation efforts as needed
- Maintain awareness of the competitive and scientific landscape in ADCs, biologics, and targeted therapeutic platforms
Benefits
- health, life and disability benefits
- a 401(k) with company contribution and match
- a generous time off package including vacation, personal days, holidays and other leaves
- performance-based cash incentive
- eligibility to be considered for annual equity awards
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
