Principal Scientist II - Pharmacology

Novartis • Cambridge, MA

6d • $126,000 - $234,000 • Onsite

About The Position

NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. This is a labhead-based position, where the ideal candidate is expected to lead efforts in the design and execution of in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to develop novel in vivo assays to interrogate key scientific questions and deliver high-value translationally relevant data that can inform clinical development. Qualified candidates will have extensive experience in a variety of molecular biology skills. A strong background and expertise in antibody drug conjugates is preferred. We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly matrixed work environment, and can effectively communicate within multidisciplinary project teams.

Requirements

• PhD with 5-8 years of research experience as a postdoc or in the pharmaceutical/biotech industry
• Deep knowledge of antibody drug conjugates
• Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models
• Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry
• Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Prism and Excel

Nice To Haves

• A strong background and expertise in antibody drug conjugates is preferred.

Responsibilities

• Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities
• Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions
• Manage associate-level scientists
• Collaborate with cross-functional project teams
• Critically analyze and present results within a multidisciplinary team environment
• Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook

Benefits

• health, life and disability benefits
• a 401(k) with company contribution and match
• a variety of other benefits
• a generous time off package including vacation, personal days, holidays and other leaves
• performance-based cash incentive
• eligibility to be considered for annual equity awards

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree