Principal Scientist, High-Content Imaging
About The Position
Johnson & Johnson is seeking a Principal Scientist, High-Content Imaging, within Mechanistic & Cellular Pharmacology in Spring House, Pennsylvania. This hands-on technical contributor will develop, validate, and deploy high-content imaging capabilities to advance therapeutic discovery across Immunology, Neuroscience, and Oncology. The role designs and executes end-to-end imaging workflows across diverse 2D and 3D cell models and tissues. It develops novel molecular assays, establishes and optimizes laboratory workflows and infrastructure, and performs technical work across imaging and assay platforms. Additional work includes building data-generation pipelines, troubleshooting experiments and imaging platforms, optimizing protocols, analyzing imaging data, and collaborating with internal teams, CROs, and external technology partners. The position applies advanced drug-discovery approaches in a multidisciplinary setting and helps translate high-dimensional readouts into actionable biological insights. It also supports data mapping, quality-control frameworks, and analytical handoffs to computational teams.
Requirements
- Ph.D. in Biochemistry, Systems Biology, Human Biology, or a related discipline.
- At least 4 years of pharmaceutical industry experience.
- Strong track record of high-impact scientific deliverables, demonstrated through publications, presentations, and recognition in the scientific community.
- Deep technical high-content imaging expertise, including understanding end-to-end workflows, method limitations, and mitigation strategies.
- Excellent written communication, verbal communication, and oral presentation skills.
- Demonstrated ability to work across disciplines and functional areas.
- Ability to apply novel approaches to complex biology questions, evidenced by strong peer-reviewed publications.
- Problem-solving and team-collaboration experience, including facilitating understanding between biologists and data scientists.
Nice To Haves
- Expertise in complex cell models and/or tissue imaging.
- Experience working with and/or guiding external collaborators in industry or academia.
- Experience integrating different types of high-dimensional data.
- Proficiency in R or Python, and/or experience using agentic AI to produce high-quality analysis code.
Responsibilities
- Develop, optimize, and validate complex high-content imaging and other high-dimensional assays for Immunology, Neuroscience, and Oncology programs.
- Establish and refine molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
- Design and execute end-to-end imaging workflows across diverse 2D and 3D cell models and tissues.
- Develop and execute novel molecular assays and optimize protocols and laboratory workflows and infrastructure.
- Build and implement data-generation pipelines and analyze imaging data.
- Troubleshoot complex experiments at the bench and across imaging platforms.
- Collaborate with colleagues and therapeutic-area teams to translate high-dimensional readouts into actionable biological insights.
- Work with CROs and external partners to support high-quality data generation, timeline alignment, and technical deliverables.
- Support data mapping, quality-control frameworks, and analytical handoffs to computational teams.
- Apply state-of-the-art drug-discovery approaches as part of a multidisciplinary team.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
