Principal Scientist - Global Drug Discovery, Obesity Pharmacology (US)
About The Position
The Principal Scientist will provide scientific leadership in the identification, validation, and advancement of new drug targets related to obesity and obesity-related comorbidities, including cardiovascular disease (CVD) and metabolic dysfunction–associated steatohepatitis (MASH). The role drives in vivo pharmacology strategies across early and late-stage obesity pipeline programs, enabling translation of novel biology into therapeutic opportunities. As a subject matter expert, the individual will define experimental strategies, guide cross-functional teams, evaluate emerging targets and technologies, and lead external collaborations. The role also includes mentoring colleagues and representing the organization through high-impact scientific contributions. The Principal Scientist will provide strategic guidance to project teams, evaluate emerging targets and technologies, and propose and oversee external collaborations and strategic partnerships. The Principal Scientist will be responsible for in vivo pharmacology supporting both early and late obesity pipeline programs and mentor junior colleagues in the department. Furthermore, the Principal Scientist will represent the organization to the external scientific community through communication of highly impactful research.
Requirements
- PhD with 10 years relevant industry or post-doctorate experience is required.
- Master’s degree with 16 years relevant industry or post-doctorate experience can be considered.
- Bachelor’s degree with 22+ years relevant experience can be considered.
- Extensive hands-on expertise in in vivo models related to Obesity, CVD, and MASH.
- Technical expertise and high attention to detail in planning and designing complex in vivo models.
- Prior experience using small molecules and/or siRNA in obesity pharmacology drug discovery.
- Experience with Obesity, MESH and CVD models (telemetry, liver elastography, metabolic cages etc.), along with alternative routes of administration in rodents (e.g., PO, SC, IV, minipump).
- Proven success leading drug discovery programs and processes in cardiometabolic biology (including, but not limited to, novel target identification, target engagement markers, and collaboration with translational and clinical teams).
- Experience applying human genetics and omics approaches for target discovery/identification.
- Demonstrated excellent verbal and written communication skills.
Nice To Haves
- Experience in women’s health is a strong plus.
- Preferred experience includes: Experience working with external CROs and/or academic collaborators.
Responsibilities
- Provide scientific leadership in the identification, validation, and advancement of new drug targets related to obesity and obesity-related comorbidities.
- Drive in vivo pharmacology strategies across early and late-stage obesity pipeline programs.
- Define experimental strategies, guide cross-functional teams, evaluate emerging targets and technologies, and lead external collaborations.
- Mentor colleagues and represent the organization through high-impact scientific contributions.
- Provide strategic guidance to project teams.
- Propose and oversee external collaborations and strategic partnerships.
- Be responsible for in vivo pharmacology supporting both early and late obesity pipeline programs.
- Represent the organization to the external scientific community through communication of highly impactful research.
- Plan and design in vivo pharmacology studies in collaboration with technical scientists.
- Advise on experimental execution, interpretation, and communication of results from complex, state-of-the-art in vivo experiments related to obesity, CVD, and MASH.
- Provide expert-level guidance to project teams on experimental strategies to evaluate emerging targets, biology, and technologies.
- Collaborate effectively across global sites to set project strategy by leading cross-functional project teams spanning in vitro, omics, translational, and clinical disciplines.
- Contribute subject matter expertise to develop the research agenda, with clear understanding of the link between scientific goals and overall long-term business needs.
- Propose new projects that support the strategic agenda and address gaps in technological capabilities and therapeutic areas related to obesity and appetite regulation.
- Represent the organization through external communication of impactful scientific research via presentations at external conferences, peer-reviewed publications, and patent activity.
- Maintain deep theoretical knowledge and remain actively connected to the external scientific community through continuous evaluation of relevant literature and emerging technologies.
- Guide and/or lead global, cross-functional experimental teams to achieve project goals.
- Provide mentorship and training to colleagues within the field of expertise.
- Maintain, identify, and initiate key relationships with KOLs and academic partners.
- Guide other research teams on suitable assays/techniques to interpret and translate in vivo studies to progress the obesity pipeline.
Benefits
- company bonus based on individual and company performance
- long-term incentive compensation
- company vehicles depending on the position's level or other company factors
- medical coverage
- dental coverage
- vision coverage
- life insurance
- disability insurance
- 401(k) savings plan
- flexible spending accounts
- employee assistance program
- tuition reimbursement program
- voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance
- time off pursuant to its sick time policy
- flex-able vacation policy
- parental leave policy
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
