Principal Scientist, Drug Product Sterile Solutions

GSK•Upper Providence, PA

4d•Hybrid

About The Position

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade. This role focuses on leading scientific work to develop safe, stable, and manufacturable drug product sterile solutions, including mAbs and oligonucleotides. The position involves designing and running studies, interpreting results, and making clear recommendations, while working closely with colleagues across science, regulatory, and supply teams. GSK values curiosity, clear communication, and a focus on patients, offering growth, real impact on development programs, and the chance to unite science, technology and talent to get ahead of disease together.

Requirements

PhD in Pharmaceutics, Chemical Engineering, Biomedical Engineering, Chemistry, or related scientific discipline; or MS with 5+ years’ relevant experience; or BS with 10+ years’ relevant experience.
Experience in formulation and process development for sterile or complex drug products.
Experience designing and executing stability and compatibility studies.
Strong data analysis skills and experience interpreting physicochemical and analytical results.
Experience authoring technical reports and contributing to regulatory documentation.

Nice To Haves

Experience with biologics, oligonucleotides, or advanced delivery systems.
Experience with container-closure integrity and primary packaging assessments.
Experience with technology transfer and scale-up to manufacturing.
Experience statistical design of experiments (DOE) and technical risk assessment methods.
Experience contributing to regulatory submissions and responding to regulatory questions.
Strong collaboration and influencing skills in matrix team environments.

Responsibilities

Design, plan and execute formulation and process development studies for sterile and complex drug products.
Interpret experimental results and provide clear recommendations to project teams.
Lead stability, compatibility, and container-closure assessments to support regulatory submissions.
Prepare technical reports, study protocols, and documentation needed for product development and transfer.
Work across functional teams and external partners to support scale-up, technology transfer, and launch readiness.
Mentor colleagues, review data quality, and contribute to continuous improvement of lab practices.
Opportunities to publish research and influence industry approaches.