Principal Scientist, Drug Product Development

Parabilis Medicines•Cambridge, MA

1d•$165,000 - $200,000•Onsite

About The Position

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution. We are seeking a Principal Scientist with deep expertise in drug product formulation development for peptide therapeutics to play a critical role in advancing Parabilis Med’s pipeline and delivery platforms from early development through clinical/commercial stages. This position will lead formulation strategies across multiple delivery modalities (parenteral, oral, and advanced delivery systems), integrate closely with discovery, DMPK, analytical, and CMC teams, and help establish Parabilis Med’s drug product development capabilities.

Requirements

PhD in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Chemistry, or related field
8-10+ years of industry experience in drug product development for peptides and/or biologics
Demonstrated expertise in multiple formulation modalities, including parenteral formulations (SC/IV/IM), and oral dosage forms
Strong understanding of biopharmaceutics, stability, release/absorption and in vitro–in vivo translation
Experience contributing to IND/CTA-enabling CMC activities
Experience working with and managing CRO/CDMO partners
Strong scientific judgment, problem-solving skills, and communication

Nice To Haves

Experience in advanced delivery systems (e.g., nanoparticles, depot formulations) is a plus.
Experience with late-stage or commercial formulations is highly desirable

Responsibilities

Lead formulation development for peptide therapeutics across parenteral (SC/IV/IM), oral, and advanced delivery systems (e.g., nanoparticles, depot formulations)
Design and optimize dosage forms including injectables, tablets, capsules, and enabling delivery technologies
Evaluate and implement high concentration peptide formulation, incorporating sustained release, absorption enhancement, and stabilization strategies
Design and interpret biorelevant in vitro and in vivo studies to support PK/PD and candidate selection
Contribute to CMC development from early feasibility through IND-enabling and clinical stages
Support technology transfer, scale-up, and external manufacturing (CRO/CDMO) activities
Collaborate cross-functionally with DMPK, biology, analytical, and regulatory teams
Provide technical leadership and mentorship within Pharmaceutical Sciences.