Principal Scientist, DMPK

Alnylam Pharmaceuticals•Cambridge, MA

3d•$147,200 - $220,800•Onsite

About The Position

The successful candidate will be part of a team responsible for understanding the disposition mechanisms and pharmacokinetic/pharmacodynamic (PK/PD) relationships of oligonucleotide therapeutics and other emerging modalities. The candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance programs from discovery through clinical development. This is an in-office position based in Cambridge, Massachusetts, requiring regular on-site collaboration with cross-functional teams.

Requirements

Ph.D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biomedical engineering, or a related scientific discipline.
Minimum of 6+ years of relevant industry experience in pharmaceutical or biotechnology drug discovery and development.
Strong understanding of ADME, pharmacokinetics, PK/PD principles, and translational pharmacology.
Demonstrated experience developing and executing DMPK strategies for discovery- and/or development-stage programs.
Direct experience contributing to CTA and/or IND filings, including preparation or review of relevant regulatory submission content.
Proven ability to work effectively and influence outcomes in highly matrixed, multidisciplinary teams.
Strong quantitative, analytical, and problem-solving skills, with experience integrating diverse datasets to drive decision-making.
Excellent written, verbal, presentation, and interpersonal communication skills, with the ability to communicate complex scientific concepts to diverse audiences.
Demonstrated ability to multitask, manage multiple projects simultaneously, meet timelines, and adapt to changing priorities.

Nice To Haves

Experience with oligonucleotide therapeutics, RNAi, ASO, antibody-oligonucleotide conjugates, peptides, antibodies, or other advanced therapeutic modalities.
Experience with modeling and simulation approaches, including population PK, PBPK, mechanistic PK/PD, or translational modeling.
Experience supporting regulatory interactions and responding to health authority questions.
Familiarity with biomarkers, translational medicine, and quantitative pharmacology approaches.

Responsibilities

Develop and implement DMPK strategies to support discovery, candidate selection, translational research, and clinical development of oligonucleotide therapeutics and other drug modalities.
Design, execute, interpret, and communicate DMPK studies to characterize absorption, distribution, metabolism, excretion (ADME), PK/PD relationships, and translational pharmacology.
Collaborate closely with Research scientists to optimize tissue delivery, pharmacology, and candidate selection for advancement into development.
Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership teams to integrate PK, PD, efficacy, safety, and biomarker data and inform development decisions.
Apply quantitative approaches, including modeling and simulation, to support dose prediction, translation, and development strategy.
Represent DMPK as a key scientific contributor on multidisciplinary, matrixed project teams and participate in program and governance discussions.
Lead or contribute to the preparation of DMPK reports, regulatory submission content, and responses supporting CTA, IND, NDA, and other global health authority filings.
Provide scientific mentorship and technical guidance to junior scientists and contribute to building DMPK capabilities across the organization.
Effectively manage multiple programs, deliverables, and priorities in a fast-paced environment while maintaining high-quality scientific output.
Present scientific findings and recommendations clearly and effectively to project teams, senior management, external collaborators, and regulatory agencies, as appropriate.