Principal Scientist/Director, Translational Pharmacology

5AM Ventures•Emeryville, CA

About The Position

We are seeking a highly motivated, hands-on Director of Translational Pharmacology to lead and drive preclinical pharmacology efforts across our pipeline. This individual will play a central, decision-making role in translating innovative science into rigorous, in vivo proof-of-concept and clinically actionable pharmacology strategies.

Requirements

PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
Experience in choosing appropriate animal models
Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design
Demonstrated experience designing and interpreting in vivo pharmacology studies
Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
Strong statistical and data analysis skills

Nice To Haves

Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred

Responsibilities

Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
Design and oversee in vivo studies, including selection and development of appropriate animal models
Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
Translate preclinical findings into clinically relevant hypotheses and development strategies
Collaborate closely with teams to optimize drug candidates and delivery systems
Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
Build and manage relationships with CROs and external collaborators