Principal Scientist, Cell Therapy Vector Engineering
About The Position
The Principal Scientist, Vector Engineering position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated scientist to own the design and screening of complex payloads to enable next-generation CAR-T cell products. Do you have industry experience building molecular engineering workflows and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.
Requirements
- PhD in Biological Engineering, Synthetic Biology, Immunology, Chemical Engineering, Virology, Biology, or related field with at least 2 years of post-PhD industry experience; or BS/MS in the above fields with 6-8 years of related experience is required
- Industry experience with evidence of scientific project leadership is strongly preferred
- Experience designing and evaluating multicomponent genetic elements in primary cells is strongly preferred
- flow cytometry
- familiarity with molecular design software (Geneious, Snapgene, Benchling)
- Strong critical, scientific, and strategic thinking skills are required
- Strong communication and organizational skills, with the ability to independently manage multiple projects in parallel, are required
- Demonstrated ability to work collaboratively in cross-functional teams is required
Nice To Haves
- primary T cell culture
- molecular biology assays (such as qPCR or ddPCR, Western blot, ELISA)
- high-throughput screening
- familiarity with DNA/RNA sequencing
- Experience with lentiviral vector payload design is preferred
Responsibilities
- Lead the design and experimental selection of genetic payloads with complex architectures (e.g. multiple expression cassettes and regulatory elements)
- Build rigorous experimental workflows to establish design rules and methods for delivering complex payloads to primary T cells
- Mentor junior colleagues to grow their experimental and analytical skills while establishing best practices within the team
- Maintain detailed records and clearly communicate designs and results to enable efficient data-driven decisions in partnership with stakeholders
- Contribute to a collaborative, creative, and rigorous culture of scientific discovery
Benefits
- inclusive work environment
- respect the diversity and dignity of our employees and recognize their merit
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
