Principal Scientist, Cell Therapy Translational Biology Research

Bristol Myers Squibb•Seattle, WA

1d•$152,360 - $184,628•Onsite

About The Position

The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes. Position Summary The candidate will join the Cellular Therapy Translational Biology Research group in Seattle, WA. Translational Biology is a lab-based research team supporting clinical-stage cell therapy assets, accelerating clinical product development by translating biology into clinical and regulatory decisions. The Principal Scientist will conduct laboratory-based research focused on clinical-stage cellular therapy assets across oncology and autoimmune indications. This includes contributing to mechanism of action studies, drug combination studies, biomarker identification, and generation of data that supports patient stratification, indication selection, and the pharmacodynamic evaluation of therapies in the clinical setting. The successful candidate will be an experienced, self-motivated, and resourceful researcher responsible for driving and implementing non-clinical development strategies across these cell therapy assets.

Requirements

Bachelor’s Degree
8+ years of academic and / or industry experience
Master’s Degree
6+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in Life Sciences
4+ years of academic and / or industry experience
M.S. or Ph.D. in immunology, molecular and cellular biology, or relevant discipline
M.S. with 6+ years or Ph.D with 4+ years of experience, preferably in the biotechnology or pharmaceutical industry setting, or demonstrated deep experience in immunology or cell therapy academic research
Expertise in immunology or cellular biology is required
Experience with Electronic Lab Notebooks (ELN) and detailed protocol/process documentation is required
Excellent communication and interpersonal skills, evidenced by strong ability to interact with and influence research scientists, project teams, and outside collaborators
Detail-oriented with the ability to identify and implement creative solutions
Ability to prioritize and manage time efficiently

Nice To Haves

knowledge of fundamentals of oncology and/or autoimmune and inflammatory diseases is desirable
Familiarity with and experience in the drug development process from IND filing to late stage development in an industry setting is desirable
Demonstrated ability to independently design, execute, and interpret complex experiments, adapting standard methods and techniques as needed
Expertise in flow cytometry and cell culture/imaging techniques
Experience with Incucyte software, JMP and GraphPad prism
Experience analyzing high content (eg, transcriptomic, proteomic) datasets

Responsibilities

Develop and lead focused research projects, exercising independent judgment in experimental design, execution, and interpretation
Plan, direct, and execute laboratory research to characterize product/candidate function and inform clinical interpretation and indication strategy
Design and lead non-clinical/translational data packages to support regulatory submissions and indication expansion for cell therapy programs
Contribute to biomarker strategy and patient stratification approaches to guide clinical decision-making
Lead the development, design, and optimization of novel in vitro assays and models to advance translational research objectives
Investigate the impact of manufacturing and process changes on product functional comparability to support regulatory filings and process decisions
Represent Translational Biology on cross-functional, multi-disciplinary program/project teams spanning Discovery, Clinical, Regulatory, and Manufacturing
Contribute to the writing of non-clinical pharmacology study reports, investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate
Coordinate external collaborations and/or be the subject matter expert
Act as a technical point of contact and functional mentor to junior scientists
Present data and analysis at cross-functional program and team meetings; contribute to conference abstracts, manuscripts, and patent disclosures
Contribute to lab stewardship initiatives to support productivity, safety, and inspection readiness

Benefits

wellbeing support
retirement and financial protection benefits
insurance offerings (medical, dental, vision, life and disability)
Flexible Time Off (FTO)
11 paid company holidays each year
160 hours of paid vacation annually for new hires
3 optional holidays
paid sick leave
up to two paid volunteer days per year
summer hours flexibility
leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
annual Global Shutdown between Christmas Day and New Year's Day