Principal Scientist Bioconjugation
About The Position
Amgen is seeking a Principal Scientist to join its DSTS group within Process Development, which invents, develops, and implements drug substance manufacturing processes and technologies for synthetic and hybrid assets. The role leads development of efficient, sustainable, and cost-effective manufacturing processes for bioconjugates, including antibody drug conjugates (ADCs), and advances bioconjugation technology and manufacturing practices. The position is located at Amgen’s Thousand Oaks, California campus. The successful candidate will bring experience in bioconjugation process development and industrialization, along with a record of scientific innovation and leadership in the pharmaceutical industry. They will provide technical expertise, support manufacturing and technology transfer, guide project delivery, collaborate on regulatory work, and develop and mentor colleagues.
Requirements
- Doctorate degree (PhD, PharmD, or MD, with relevant postdoctoral experience where applicable) and 2 years of scientific experience; or a master’s degree and 5 years of scientific experience; or a bachelor’s degree and 7 years of scientific experience.
Nice To Haves
- Doctoral degree and 4 or more years of pharmaceutical industry experience, with expertise in bioconjugate process development, preferably ADCs and HPAPI linker-payload synthesis.
- Experience with GMP manufacturing and technology transfer to CMOs.
- Demonstrated functional representation on a CMC or PDT team.
- Ability to work in a dynamic, interdisciplinary environment to achieve results.
- People-centered leadership skills, including building strong teams through mutual trust and respect and demonstrating Amgen’s leadership attributes of inspire, accelerate, integrate, and adapt.
- A proven track record of publications, patents, and presentations.
Responsibilities
- Lead a multidisciplinary project team developing sustainable and cost-effective bioconjugate manufacturing processes at all stages of clinical development.
- Drive bioconjugation technology innovation.
- Support cGMP manufacturing and technology transfer to GMP production facilities.
- Develop strategies to ensure process performance through process understanding, modeling, and characterization.
- Guide completion of project deliverables and ensure timelines are met.
- Work cross-functionally to deliver regulatory documents and support regulatory filings.
- Serve as a technical expert and remain current in bioconjugation manufacturing.
- Coach colleagues and provide career and scientific or technical advice.
Benefits
- Health and welfare plans for staff and eligible dependents.
- Financial plans with opportunities to save for retirement or other goals.
- Work/life balance and career development opportunities.
- Retirement and Savings Plan with generous company contributions.
- Group medical, dental, and vision coverage.
- Life and disability insurance.
- Flexible spending accounts.
- Discretionary annual bonus program, or a sales-based incentive plan for field sales representatives.
- Stock-based long-term incentives.
- Award-winning time-off plans.
- Flexible work models where possible.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Principal
