Principal Scientist, Biochemistry & Biophysics

C4 Therapeutics Inc • Watertown, MA

8d • $184,851 - $204,309

About The Position

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com [http://www.c4therapeutics.com].

Requirements

• A PhD in biochemistry, biophysics, chemical biology, enzymology, or a closely related discipline, with at least eight years of post-graduate experience, including significant experience in a biotechnology or pharmaceutical drug discovery setting.
• Demonstrated expertise in quantitative characterization of protein–protein and protein–small molecule interactions, including assay design, data analysis, troubleshooting, interpretation, and strategic application of biochemical and biophysical methods for small-molecule discovery.
• Proven ability to lead complex scientific operations across multidisciplinary teams, including prioritizing workstreams, coordinating stakeholders, managing dependencies, and delivering high-quality outputs under aggressive timelines.
• Experience contributing to early-stage drug discovery programs and using biochemical or biophysical data to guide SAR, compound prioritization, and program decision-making.
• Excellent communication, accountability, and organizational skills, with the ability to explain complex technical information, data limitations, and recommended next steps to both scientific and non-specialist audiences in a fast-paced, collaborative environment.

Nice To Haves

• Experience in targeted protein degradation, including characterization of heterobifunctional degraders, molecular glues, E3 ligase biology, ternary complex formation, cooperativity, and degradation-relevant mechanisms.
• Familiarity with structural biology, computational chemistry, DEL screening, proteomics, or cell pharmacology workflows and how these inputs integrate with Lead Discovery decisions.
• Experience with management activities for full-time employees, including coordinating workloads, coaching and mentorship, and performance management activities.

Responsibilities

• Provide scientific and operational leadership for biochemical and biophysical assay strategies that support efforts in hit validation, hit-to-lead, lead optimization, and mechanistic characterization of molecular glue degraders and heterobivalent degraders.
• Design, develop, optimize, and oversee assays to characterize protein–protein interactions, protein–small molecule interactions, and ternary complexes including binding kinetics and functional activity.
• Apply deep expertise in biochemical and biophysical methods such as SPR, BLI, TR-FRET, AlphaLISA, fluorescence polarization and related approaches to generate high-quality data.
• Lead complex operational workstreams across multidisciplinary teams, ensuring alignment on goals, priorities, timelines, experimental plans, data quality expectations, and decision points.
• Integrate data across assay formats and functional disciplines to provide clear interpretation, identify key risks and limitations, recommend next experiments, and influence compound prioritization and program strategy.
• Serve as a senior scientific thought partner to project teams and functional leaders, helping to translate biochemical and biophysical insights into actionable drug discovery decisions.
• Manage CRO relationships and external collaborations as needed, including assay transfer, protocol development, troubleshooting, data review, timelines, budgets, and performance expectations.
• Drive rigorous experimental design, assay validation, data reproducibility, and transparent communication of results, limitations, and recommendations.
• Mentor and influence scientists across the organization through technical guidance, cross-functional collaboration, and leadership by example, without requiring formal people management responsibilities.
• Contribute to the evolution of C4T’s Lead Discovery capabilities, including the identification and implementation of new technologies, workflows, and platform improvements that strengthen targeted protein degradation discovery.

Benefits

• The base pay range for this position at commencement of employment is expected to be between $184,851.00 and $204,309.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree