Principal Scientist/Associate Director, Proteomics (On-Site)

Neomorph•San Diego, CA

8d•Onsite

About The Position

Neomorph is seeking an experienced and innovative Principal Scientist / Associate Director to lead and expand our proteomics and mass spectrometry capabilities to support our molecular glue targeted protein degradation platform and pipeline. This individual will play a central role in scaling high-quality quantitative proteomics workflows to support discovery and translational research efforts as the company grows. The successful candidate will combine deep technical expertise in modern LC-MS proteomics with a strong understanding of assay development, quantitative rigor, and platform growth. This role offers the opportunity to help shape Neomorph’s next-generation proteomics infrastructure, including new instrumentation, automated workflows, and future team growth, while partnering closely with teams across biology, translational sciences, chemistry, and computational biology.

Requirements

PhD in Proteomics, Biochemistry, Molecular/Cell Biology, or a related discipline and 8+ years of relevant experience (Principal Scientist), or 10+ years of relevant experience (Assoc Dir)
Deep expertise in mass spectrometry-based proteomics, including extensive hands-on experience with quantitative LC-MS/MS workflows and high-resolution mass spectrometry instrumentation
Demonstrated experience independently developing and implementing robust, reproducible, and scalable proteomics assays and workflows in biotech, pharmaceutical, or translational research environments
Strong understanding of experimental design, data analysis, and interpretation of complex proteomics datasets
Excellent communication, organizational, and scientific problem-solving skills

Nice To Haves

Experience developing and applying DIA-based proteomics workflows
Experience with specialized proteomics approaches such as post-translational modification (PTM) profiling, interaction proteomics, or other specialized mass spectrometry workflows
Familiarity with laboratory automation, high-throughput workflows, and strategies to increase proteomics platform capacity and scalability
Experience with targeted mass spectrometry assay development for translational or clinical applications
Experience supporting targeted protein degradation or broader drug discovery programs
Prior experience contributing to proteomics platform expansion, instrumentation growth, or team development

Responsibilities

Lead the continued expansion and evolution of Neomorph’s mass spectrometry-based proteomics capabilities in support of our targeted protein degradation platform and discovery pipeline
Develop and scale advanced quantitative proteomics workflows with a focus on throughput, reproducibility, automation, and operational excellence
Drive implementation of new technologies, instrumentation, and proteomics approaches to expand platform capabilities and capacity
Partner cross-functionally with biology, translational sciences, chemistry, and computational teams to support discovery and translational research efforts
Contribute to scientific strategy, experimental design, data interpretation, and long-term platform development
Mentor junior scientists and contribute to the continued growth of Neomorph’s proteomics function

Benefits

Industry competitive compensation
Annual target bonus
Stock options
401K plan
Career advancement opportunities
Monthly town halls to share business and scientific updates
Work Hard, Stay Well
Comprehensive medical, dental, and vision plans for employees and their dependents
Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
Employee Assistance Program
10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
Supplemental pay for Pregnancy Disability Leave
Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Lifestyle
Casual work environment
Volunteer days off each year to spend time contributing to causes you care about
Flexible work schedule
Access to onsite gym
Onsite space to store your bicycle (or surfboard)
Have Fun!
We believe in work/life balance and Fun is at the core of our Core Values.
In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).