Principal Scientist, Analytical Development

Bristol Myers Squibb • Cambridge, MA

2d • $137,810 - $166,994 • Hybrid

About The Position

Bristol Myers Squibb (BMS) is looking for an experienced Senior or Principal Scientist specializing in Analytical Development. The ideal candidate will play a pivotal role in advancing analytical methods to support the development and manufacturing of innovative RNA therapeutics. Key responsibilities will center on the utilization of chromatography and mass spectrometry for method development, with a focus on creating and implementing assays to characterize both RNA drug substance and lipid nanoparticle (LNP) drug products.

Requirements

• Ph.D. in Analytical Chemistry, Biochemistry, or a related discipline with at least eight years of Chemistry, Manufacturing, and Controls (CMC) experience. Candidates with a B.S. or M.S. and relevant experience will also be considered.
• Extensive experience analyzing various sample types using chromatography (HPLC/UPLC) across different separation modes, including reversed phase, ion exchange, size exclusion, and asymmetric flow field-field-flow fractionation.
• Proficiency in associated detection methods such as mass spectrometry (MS), multi-angle light scattering (MALS), and charged aerosol detection (CAD) is required.
• Demonstrated problem-solving abilities and the capacity to work both independently and collaboratively within a team.
• Strong attention to detail when executing assays and documenting results.

Nice To Haves

• Hands-on expertise in method development and impurity characterization for LNP-related impurities using various detection techniques is highly desirable.
• Experience with RNA/oligonucleotides, lipid nanoparticles, and/or proteomics is strongly preferred.
• Familiarity with Good Practice (GxP) principles for development, documentation, and qualification is preferred.
• Experience with early-stage product development is advantageous.

Responsibilities

• Serve as a subject matter expert in separation science, developing novel analytical methods to characterize RNA-based products and their delivery systems.
• Investigate new techniques and technologies to provide analytical support for research and development activities across different stages of product development.
• Establish methods to identify and characterize impurities related to LNP drug products and assess critical quality attributes of protein-conjugated LNPs.
• Participate in the transfer of methods to internal and external testing laboratories as necessary, providing expertise and documentation—including standard operating procedures (SOPs), technical reports, and method qualification plans—to facilitate method verification, qualification, and validation.
• Collaborate with internal teams, including RNA Process Development (PD), LNP PD, research, and preclinical manufacturing, as well as broader BMS groups, to meet program timelines and support routine testing requirements.
• Lead troubleshooting efforts and provide guidance when analytical challenges arise.
• Supervise routine analytical testing, review data, and perform testing as needed.
• Operate and maintain essential instruments such as high-performance liquid chromatography (HPLC) and mass spectrometry.
• Document and communicate results effectively to team members and leadership.
• Approach analytical challenges with creativity, contributing to the development of a cutting-edge analytical platform.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree