Principal Scientist - ADME - Site Based, Princeton, NJ

Cyprotex•Princeton, NJ

3d•$113,900 - $154,100•Onsite

About The Position

At Cyprotex US, an Evotec company, we believe that curiosity is the spark that drives innovation and success. As a forward-thinking team, we thrive on challenging the status quo, learning from each other, and pushing the boundaries of what’s possible. We're on a mission to create a place where curiosity isn't just encouraged—it’s celebrated. Cyprotex US specializes in ADME-Tox and Biosciences including both in vitro (laboratory experiments) and in silico (computer modelling) approaches. Cyprotex was founded in 1999. The Company serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals Industries as well as academia and not-for-profit organizations. Over 1700 organizations trust Cyprotex for their ADME-Tox and Bioscience research needs.

Requirements

PhD (5+ years experience) in biology, chemistry, pharmaceutical sciences, or an equivalent combination of education, training and experience from which comparable knowledge, skills and abilities have been attained.
Excellent writing and verbal communication skills that enable the candidate to function effectively on a collaborative multi-disciplinary work team.
Very strong organization skills and attention to detail.
Detailed knowledge of bioanalysis within ADME/DMPK.
Hands-on experience of bioanalytical method development and quantification of small molecules and peptides in complex matrices.
Strong understanding of UPLC-MS/MS systems.
Troubleshooting skills in assays and instrumentation.
An understanding of pharmacokinetic parameter determination and interpretation.
Experience locating and applying information in the scientific literature.

Responsibilities

Working closely with other members of the team managing both client and R&D projects, ensuring these are performed to a high standard and within scheduled time-frames.
Supporting the training and development of staff, improving the team’s knowledge and processes.
Working with the VP to create and cascade the short and medium term vision and strategy for the team.
Acting as a senior point of contact within the group for operational and scientific support across all ADME assays (troubleshooting, data analysis and interpretation).
Identifying opportunities for and leading cross-functional collaboration.
Designing and performing novel ADME assays.
Conducting in vitro ADME assays manually or using automated liquid handling system for completion in a fast-paced environment, while managing multiple projects to meet the timelines.
Performing Bioanalytical method development and quantification using UPLC-MS/MS.
Actively participating in scientific discussion to resolve arising issues as well as critically analysing and interpreting the data to design next steps.
Working closely with project managers and senior management to complete the assigned work in the anticipated time frame.
Providing expert scientific support for the wider company for ADME studies.
Keeping up to date with scientific literature advances, developments, and regulatory guidelines in the area of ADME and informing the team of relevant developments.
Providing practical scientific guidance to others, collaborating across functions to meet project goals, and regularly presenting findings.
Promoting cross-functional collaboration with other Principal Scientists and to provide opportunity for team members to contribute to these collaborations.
Providing expert scientific support for the wider company for drug metabolism studies.
Coaching, mentoring and line managing other members of the team by effective use of Evotalks meetings, regular 1to1 discussions and ad hoc interactions.
Assisting team members in generating development plans and to review and provide support to team members in executing these plans.
Assisting the VP in generating succession plans for the team.
Managing and coordinating multiple projects/activities within the group with a results-driven approach.
Proactively taking the initiative to improve group processes and make efficiency gains in assays.
Encouraging a continuous improvement culture and to manage projects to completion.
Participating in internal and external partner meetings as and when required.
Ensuring appropriate Health and Safety procedures are always followed in the workplace.
Participating in all mandatory training required to perform effectively in job role.
Ensuring that your personal training record is up to date and that any gaps are discussed with your supervisor.
Actively participating in Evotalks and agreeing on personal targets and expectations with supervisor.