Principal Research Scientist, QTAS & ADME Sciences

AbbVie•North Chicago, IL

1d•Onsite

About The Position

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise in drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis, ability to drive cutting-edge science and lead a team of junior scientists. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working in a laboratory and non-laboratory setting, the position will involve the conduct and scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to implement and/or evaluate new technologies and approaches to support the mechanistic and translational understanding of early and late-stage small molecules to facilitate rapid advancement of drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

Requirements

BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in area or scientific area of discipline
Experience with in vitro ADME experiments and DMPK projects, through academic or industry work.
Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment
Strong and relevant publication record as well as a track record of strategic scientific leadership in the in vitro ADME field
Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor
Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.

Nice To Haves

Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable.

Responsibilities

Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential
Lead, mentor and coach junior staff in established and novel practices in vitro drug metabolism
Liaise with QTAS, discovery biology/pharmacology/chemistry scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
Communicate internally and externally on topics related to in vitro drug metabolism
Keep up to date with emerging literature and science in modeling and in vitro approaches
Externalize research in the form of full length publications and oral presentations.