Principal Research Scientist II, Process Chemistry (Radiochemistry)
About The Position
AbbVie Process Chemistry is responsible for the chemical development of AbbVie’s clinical candidates. We are seeking a Principal Research Scientist II to lead the Radiochemistry team that is responsible for labeling experimental drug candidates from preclinical through clinical development. We are looking for a highly motivated person who can drive the development of drug candidates from early discovery to late-stage development through radiolabeling. The candidate will lead a group of scientists in the labeling of materials with tritium and 14C. The candidate will serve as the primary contact for labeling requests and as such would be responsible for developing strategies, timelines, and key activities required for radiolabeled drug substances. The candidate must be able to mentor and develop staff with experimental approaches to solve difficult scientific and technical challenges. Working with discovery, drug metabolism, analytical and chemistry colleagues, the candidate will develop productive collaborations and effectively communicate with scientific teams.
Requirements
- BS (16+ years); MS (14+ years) or PhD (8+ years) in Chemistry or allied field, with 8+ years of previous work experience in a pharmaceutical laboratory setting.
- Experience in radiolabeling and safety.
- Experience in managing and developing scientific leaders is required.
- A strong understanding of synthetic organic chemistry, process development, GXP compliant processes, and radiolabeling strategies to appropriately label compounds to meet the study needs.
Responsibilities
- Lead activities associated with labeling and characterization for new drug substances.
- Lead the design and execution of labeling strategies.
- Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
- Author and review key regulatory documents, laboratory data, technical memos, standard operating procedures, and reports.
- Collaborate to ensure successful CMC interactions with regulatory authorities.
- The position involves multi-disciplinary interactions with organic chemists, analytical chemists, engineers, drug metabolism scientists, formulators, and program management. The candidate will utilize his/her expertise across disciplines to advance the pipeline.
- Encourage ideas for continuous improvement activities and initiatives within the Radiochemistry team.
- Understand, adhere, and ensure compliance with corporate standards regarding code of conduct, safety, radiosafety and GXP compliance.
Benefits
- paid time off (vacation, holidays, sick)
- medical/dental/vision insurance
- 401(k)
- long-term incentive programs
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What This Job Offers
Job Type
Full-time
Career Level
Senior
