Principal Research Scientist II, Gastroenterology, Immunology Discovery Research

AbbVie•Worcester, MA

10h

About The Position

AbbVie’s Immunology Discovery Research organization seeks an impactful scientific leader to manage pioneering research in Gastroenterology/IBD. A successful candidate should have a deep understanding of mucosal immunology, and will lead a team of discovery scientists within the broader Gastroenterology team focused primarily on delivering novel therapeutics from target identification through preclinical development and first-in-human studies. A deep understanding of establishing and validating novel disease-relevant translational endpoints, both immune and non-immune, in drug development as well as a proven track record of delivering drug candidates to various stages within the discovery pipeline are essential. Candidates should also be able to demonstrate their ability to work cross-functionally in matrixed teams including management of collaborative external partnerships to advance innovative, patient-centric discovery programs. This role requires strong scientific, people leadership, and strategic thinking. The individual will: Integrate emerging scientific trends, patient-derived data, and utilization of humanized complex in vitro models (CIVMs) to identify/validate novel therapeutic targets for the treatment of IBD. Demonstrate exceptional strategic thinking by developing and executing robust research and drug discovery strategies that align with organizational objectives and drive innovation in autoimmune disease research. Provide scientific guidance and set direction for assay development, risk management, and research productivity. Ensure high-quality experimental design, incorporating early risk assessments and contingency planning. Foster cross-functional engagement across internal and external groups, including Chemistry, Biotherapeutics, Genetic Medicine, Precision Medicine, Clinical Development, and outside collaborations. Demonstrates exceptional ability to lead within a highly matrixed environment, effectively managing a team engaged across multiple programs and projects Actively participate in shaping overall disease area and target identification strategies, impacting the research group’s long-term vision and priorities. Communicate research progress and scientific direction to executive stakeholders. Champion mentorship and inclusive team culture, upholding AbbVie’s corporate standards. An ideal candidate will have a background in mucosal immunology including both immune and non-immune cells and a proven track record for leading discovery programs from early-stage conception to clinical candidate selection.

Requirements

Master’s Degree Science or PharmD with 14 years of related work; PhD in Science or related field with 8 years of related work experience.
Working knowledge of different primary humanized CIVM models, including organoid-based models
At least 15 years of industrial drug discovery experience, including significant leadership of teams and projects.
Demonstrated experience managing and developing a team of direct reports across a range of career levels.
Track record of leading successful drug discovery initiatives from early research through preclinical and clinical transition.
Profound expertise in immunology and hands-on experience in both in vitro and in vivo pharmacology (including PKPD and assay development).
Collaborative and inclusive leadership style with strong communication and interpersonal skills, able to effectively interact with diverse teams and stakeholders.

Nice To Haves

Deep understanding of mucosal immunology
Deep understanding of establishing and validating novel disease-relevant translational endpoints, both immune and non-immune, in drug development
Proven track record of delivering drug candidates to various stages within the discovery pipeline
Ability to work cross-functionally in matrixed teams
Management of collaborative external partnerships
Background in mucosal immunology including both immune and non-immune cells

Responsibilities

Lead, manage, and develop a high-performing research team, ensuring their professional growth across all career stages.
Oversee the planning and execution of in vitro and in vivo pharmacology studies, including the development and application of humanized CIVMs and PKPD assessments.
Direct drug discovery programs, driving progression from early-stage conception to clinical candidate selection through strategic leadership and collaboration.
Devise and implement research strategies that address critical scientific objectives and adapt to new internal and external scientific trends.
Collaborate across multidisciplinary teams and with external research partners to accelerate program advancement.
Develop and execute risk mitigation strategies and maintain study quality via robust experimental design, data analysis, and early contingency planning.
Promote knowledge sharing by authoring publications and presenting to cross-functional and executive leadership as well as external partners.
Mentor and train direct reports, fostering an environment that supports diversity, inclusion, and ongoing career development.