Principal Quantitative Scientist

Roche • Indianapolis, IN

18d • Hybrid

About The Position

Roche Diagnostics’ Roche Information Solutions (RIS) develops clinical decision support software and insights intended to improve research outcomes and patient care. This role provides scientific leadership in real-world data (RWD) and evidence generation to shape the development and adoption of Roche’s digital health and in-vitro diagnostic portfolio. The work uses varied data, including electronic health records, claims, omics, and digital health data. The position requires working onsite in Indianapolis three days per week; candidates must be willing to work onsite, and relocation benefits are not available.

The position leads complex RWD studies from conceptualization and planning through execution and reporting, and influences business, regulatory, market access, reimbursement, and strategic decisions. It also represents Roche with external partners and provides methodological leadership, mentorship, and innovation across the RWD function.

Requirements

• PhD (preferred) or master’s degree in a quantitative science field, such as pharmacoepidemiology, epidemiology, RWD biostatistics, pharmacoeconomics, health economics and outcomes research, or a related field.
• At least 7 years of directly related experience in industry, consulting, or another relevant setting, with increasing responsibility and independent scientific leadership.
• Exceptional track record using RWD to support successful and complex regulatory submissions.
• Deep mastery of epidemiology and causal inference methodologies, including the ability to debate and defend methods to external regulatory and health technology assessment bodies.
• Strong programming experience with R, Python, SQL, and/or other quantitative software.
• Strong experience using diverse RWD sources to generate insights and evidence.
• Hands-on experience designing, implementing, and reporting high-impact RWD studies, with expertise in advanced epidemiology.
• Comprehensive, forward-looking understanding of regulatory guidelines and ability to use RWD to influence national and international reimbursement and clinical guidelines.
• Demonstrated ability to lead projects of significant scope and complexity and mentor and guide senior team members.
• Excellent communication and collaboration skills, including ability to negotiate with and influence senior leaders and external stakeholders without formal authority.
• Data-savvy, creative, resilient problem-solving approach; enterprise-wide ownership, attention to detail, willingness to learn, and ability to act as a dependable team player and critical thought partner.
• Willingness to work onsite in Indianapolis.

Nice To Haves

• PhD in a quantitative science field; a master’s degree is also accepted.
• Passion for making a difference in healthcare.

Responsibilities

• Lead the conceptualization, planning, execution, and reporting of complex RWD studies using research and commercial healthcare databases.
• Develop RWD study protocols and independently lead complex analyses supporting evidence needs across the IVD and digital health portfolio and multiple therapeutic areas.
• Ensure RWE study design, execution, and presentation meet high scientific and methodological standards.
• Work with cross-functional stakeholders, including Product Leads and Medical Affairs, to align RWD projects with commercial, market access, and regulatory needs.
• Promote RWD as a supplement to clinical evidence and identify and implement opportunities to use RWD as a primary evidence mechanism for regulatory and reimbursement objectives.
• Represent Roche as a subject matter expert with KOLs, academic institutions, and healthcare authorities; lead joint publications on study design and build relationships to explore data assets and analytical methods.
• Set best practices for the RWD function as an internal authority on RWD sources, epidemiology, and advanced methodologies.
• Define and implement improved processes, methods, and technology, and share learnings with colleagues.
• Mentor junior colleagues and guide senior team members; serve as an influential subject matter expert across the organization.
• Lead projects of significant scope and complexity and influence senior leaders and external stakeholders without formal authority.

Benefits

• A discretionary annual bonus may be available based on individual and company performance.
• Benefits are available as detailed through the link referenced in the posting; specific benefits are not listed.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior