Principal Quantitative Scientist

Roche • Indianapolis, IN

1d • $124,500 - $231,100 • Hybrid

About The Position

Roche Diagnostics’ Roche Information Solutions (RIS) develops decision-support software and insights intended to improve research outcomes and patient care. The Senior Principal Quantitative Scientist serves as a scientific authority for real-world data (RWD), leading evidence generation that informs development and adoption of digital health and in-vitro diagnostics (IVD) products. The role is independent, high-impact, and externally facing, and uses data such as electronic health records, claims, omics, and digital health data to inform scientific, business, regulatory, and strategic decisions.

The position requires working on-site in Indianapolis three days per week. The scientist leads complex RWD studies from concept through reporting, provides strategic and methodological guidance, works with internal and external stakeholders, and mentors colleagues. Relocation benefits are not available. The stated salary range is $124,500–$231,100, with a discretionary annual bonus potentially available based on individual and Company performance.

Requirements

• PhD or Master’s degree in a quantitative science field such as pharmacoepidemiology, epidemiology, RWD biostatistics, pharmacoeconomics, health economics and outcomes research, or a related field; a PhD is preferred.
• At least 7 years of directly related experience in industry, consulting, or another relevant setting, with increasing responsibility and independent scientific leadership.
• Exceptional track record using RWD to support successful and complex regulatory submissions.
• Mastery of epidemiology and causal inference methodologies, including the ability to debate and defend methods to external regulatory and health technology assessment bodies.
• Strong programming experience with R, Python, SQL, and/or other quantitative software.
• Strong experience using diverse RWD sources to generate insights and evidence.
• Hands-on experience designing, implementing, and reporting high-impact RWD studies.
• Comprehensive understanding of regulatory guidelines and ability to use RWD to influence national and international reimbursement and clinical guidelines.
• Demonstrated ability to lead projects of significant scope and complexity and mentor and guide senior team members.
• Excellent communication and collaboration skills, including the ability to negotiate with and influence senior leaders and external stakeholders without formal authority.
• Ability to work on-site in Indianapolis.

Nice To Haves

• Recognized expertise in advanced epidemiology and a passion for making a difference in healthcare.
• Forward-looking regulatory and strategic acumen.
• A resilient, can-do attitude; creative problem-solving; enterprise-wide ownership; attention to detail; eagerness to learn; and ability to act as a dependable team player and critical thought partner.

Responsibilities

• Drive the conceptualization, planning, execution, and reporting of complex RWD studies using research and commercial healthcare databases.
• Develop RWD study protocols and independently lead complex analyses to support evidence needs across the IVD and digital health portfolio and multiple therapeutic areas.
• Ensure RWE study design, execution, and presentation meet high scientific and methodological standards.
• Work with cross-functional stakeholders, including Product Leads and Medical Affairs, to align RWD projects with commercial, market access, and regulatory needs.
• Champion use of RWD to supplement clinical evidence and identify and implement opportunities for RWD to serve as the primary evidence mechanism for regulatory and reimbursement objectives.
• Represent Roche as a subject matter expert with external partners, including key opinion leaders, academic institutions, and healthcare authorities.
• Lead joint publications on study design and build relationships to explore data assets and analytical methodologies.
• Set best practices for the RWD function as an internal authority on RWD sources, epidemiology, and state-of-the-art methodologies.
• Define and implement improved processes, methods, and technology, and share learnings with peers.
• Mentor junior colleagues and act as an influential subject matter expert across the organization.
• Lead projects of significant scope and complexity and mentor and guide senior team members.

Benefits

• A discretionary annual bonus may be available based on individual and Company performance.
• The position qualifies for company benefits; specific benefits are not listed in the posting.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal