Principal Medical Scientist (Biopharmaceutical) - Oxford

ISR Recruitment

1d

About The Position

ISR Recruitment is supporting a leading organisation seeking an experienced Principal Scientist in Immunology to lead research supporting the discovery and development of novel biologic therapies for autoimmune diseases. The role combines hands-on research expertise with team leadership, advancing early-stage discovery programmes and delivering robust preclinical data to support progression towards development. It is based in the Oxford area and is offered on an initial 12-month temporary contract.

Requirements

• PhD in Immunology or a closely related scientific discipline.
• At least five years of relevant research experience.
• Strong expertise in immunology, autoimmune disease pathogenesis and inflammation research.
• Proven experience in drug discovery, target identification and therapeutic development, ideally within the pharmaceutical or biotechnology industry.
• Broad technical capability across cutting-edge in vitro and in vivo immunology assays and models.
• Demonstrable scientific leadership and team mentoring.
• A strong publication record.

Nice To Haves

• Drug discovery and therapeutic development experience within the pharmaceutical or biotechnology industry.

Responsibilities

• Lead, mentor and develop a laboratory-based scientific team.
• Design and oversee rigorous in vitro pharmacology assays to investigate autoimmune disease mechanisms and support therapeutic antibody discovery.
• Plan and coordinate in vivo efficacy studies with internal teams and contract research organisations (CROs).
• Develop endpoint analysis and ex vivo profiling to understand drug mechanisms of action.
• Collaborate with multidisciplinary teams across immunology, protein engineering, chemistry, biomarkers and translational medicine.
• Identify novel targets, therapeutic approaches and technologies to strengthen the preclinical pipeline.
• Contribute to research reports, IND documentation, patent filings, publications and conference presentations.

What This Job Offers

• Career Level: Principal
• Education Level: Ph.D. or professional degree