Principal Mechanical Engineer, Fluidics Research & Early Development

Roche•Santa Clara, CA

7d•$110,600 - $205,500•Onsite

About The Position

At Roche, we are developing the next-generation of sequencing systems. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are also broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing workflows. Our Systems Technology Group, a part of Roche Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking a Principal Mechanical Engineer to contribute to the design, development, characterization, and integration of cutting-edge sequencing systems. This is a hands-on role focused on solving the fluidic and consumable challenges at the heart of our next-generation platforms. We are looking for someone who exhibits a high degree of motivation, independence, and resourcefulness to help us develop solutions to our automation challenges in a fast-paced and collaborative environment.

Requirements

Degree in Mechanical Engineering, or a closely related discipline, with relevant years of industry experience (7+ years for a Bachelor's, 5+ years for a Master's, or 3+ years for a PhD).
Demonstrated hands-on experience designing, developing, and testing complex fluidic manifolds, consumable interfaces, or moving mechanisms, preferably for life science or diagnostic instrumentation.
High level of proficiency with Python for device control, automated test bench execution, and data acquisition/analysis.
Strong background in experimental design for fluidic characterization.
High level of proficiency with machine shop tools, measurement equipment, and rapid prototyping technologies.
Demonstrated expertise in SolidWorks for detailed assembly design and the creation of manufacturing drawings.
Demonstrated troubleshooting skills, with a solid understanding of physics, chemistry and engineering fundamentals.

Nice To Haves

Experience with plastic bonding techniques and injection molding principles.
Experience utilizing CFD or FEA tools to guide fluidic and thermal design decisions.
Experience developing DNA sequencing, DNA synthesizers and other complex fluidic automation instrumentation.
Experience using diagramming tools to map out fluidic architectures and explain complex mechanical-to-chemistry interfaces to non-experts.
Demonstrated track record of acting as the engineering bridge between scientists and the hardware/consumables team.
Excellent organizational skills with the ability to manage multiple project tracks efficiently and thrive in ambiguous, fast-paced environments.
Understanding of the sequencing space with the ability to speak to technical, business, and market trends.
Experience with advanced microfabrication techniques, including lithography, thin-film deposition and wet etching of metals and inorganic materials.
Experience with optical systems and image analysis for detection and inspection of parts and the monitoring of dynamic processes.

Responsibilities

Contribute to architecture, design, research and early development of specialized consumables and mating mechanisms.
Contribute to the layout, prototyping, and characterization of new fluidic circuits and architectures.
Design, build, and assemble custom test fixtures to support testing of fluidic subsystems and novel consumables.
Translate high-level system and assay requirements into fluidic schematics, system architectures and concepts to evaluate, compare, and downselect design paths.
Create and maintain comprehensive design documentation for your sub-systems, including detailed 3D CAD models, manufacturing drawings, and material specifications with a focus on chemical compatibility and robustness.
Conduct cross-functional design reviews.
Present progress, data, and engineering decisions clearly to stakeholders.