Principal Investigator- Vaccines (Oceanside, CA)

Profound Research • Oceanside, CA

4d • Onsite

About The Position

Profound Research partners with community physicians to offer clinical trials as a therapeutic option for their patients. We handle all infrastructure, regulatory compliance, and administrative operations so physicians can focus on patient care. Our model gives patients access to the newest therapies while maintaining the trusted patient-physician relationship.
Our Mission: Improving Lives by Providing Advanced Therapeutic Options
Our Vision: Creating the Absolute Best Patient-Physician Experience in Clinical Research
Our Values:
Compassion:
We prioritize the patient-physician relationship, ensuring every interaction is service-oriented and patient-centered.
Urgency:
We work hard and practice selflessness, acting swiftly and decisively to meet the needs of our patients, partners, and colleagues.
Solution Orientation:
We embrace challenges with a positive mindset, communicate directly, and identify and implement effective solutions with efficiency.
Excellence:
We insist on excellence, holding ourselves accountable and empowering each other to deliver best-in-class service while maintaining the highest ethical and scientific standards.

Requirements

• MD or DO with an active, unrestricted California medical license
• Prior experience conducting clinical research, with working knowledge of ICH/FDA/GCP guidelines and regulatory requirements
• Proven ability to lead and collaborate with a multi-disciplinary clinical research team
• Strong communicator with patients, caregivers, clinical staff, and sponsor representatives
• High ethical standards, professional integrity, and a genuine passion for direct patient interaction

Nice To Haves

• Established relationships with community physicians or patient populations in the San Diego area
• Familiarity with CTMS platforms and electronic data capture systems

Responsibilities

• Serve as the physician of record for clinical trials at an assigned site, assuming overall responsibility for the safe and compliant conduct of each study
• Evaluate participants for enrollment eligibility and monitor their safety, well-being, and response to therapy throughout their trial participation
• Ensure every participant is treated with respect and experiences the kind of thoughtful, patient centered care that reflects Profound’s values
• Provide clinical leadership and oversight to the on-site research team, delegating responsibilities appropriately and keeping staff informed and aligned
• Maintain a thorough working knowledge of each protocol – including visit schedules, endpoint criteria, and investigational product requirements – and ensure the trial is conducted accordingly
• Oversee informed consent, adverse event documentation, and all required safety reporting to the sponsor and IRB
• Ensure data accuracy and completeness across case report forms and source documents, and support the site’s readiness for monitoring visits and audits
• Collaborate effectively with sponsors, the IRB, and the Profound Research team throughout the life of the trial

Benefits

• Competitive compensation
• health insurance
• PTO
• retirement plan
• professional development support

What This Job Offers

• Job Type: Full-time
• Career Level: Principal