Principal Investigator/Bioanalytical Lead Scientist I- (LC-MS)

Labcorp•Madison, WI

7d•Onsite

About The Position

Labcorp is seeking a Principal Investigator/Bioanalytical Lead Scientist I specializing in LC-MS to join its team in Madison, Wisconsin. The position leads scientific work supporting external methods and projects and serves in applicable scientific roles for non-regulated, GLP-regulated, and GCP-regulated studies. The role ensures client programs meet Labcorp, client, and regulatory requirements and milestones throughout drug development. The scientist develops and reviews protocols and sample analysis plans; works with method development teams to assess readiness for validation; approves validation methods; reviews sample analysis methods; and independently reviews and approves raw data. The role identifies and documents circumstances that could affect study quality or integrity, supports appropriate corrective action, evaluates data and tables against regulatory expectations, and reviews and approves scientifically accurate and complete reports. It also supports on-time delivery of high-quality data and reports, troubleshooting, scientific investigations, QA project inspections, data archival, technical feasibility evaluations, and scientific publications or presentations. As the scientific point of contact for clients, the role determines project requirements, leads pre-initiation meetings when needed, directs study teams scientifically, identifies scientific issues or scope changes, and communicates expectations to staff and clients. It supports client satisfaction and visits, experimental design outside SOP scope, and responses to unscheduled deadlines and client needs. The position promotes quality, collaboration, and a positive impression of Labcorp; provides technical resources and guidance to clients, other departments, and less experienced team members; leads new employee training; identifies process improvements; and advocates Labcorp’s ethics, vision, and values. The scientist may support other lead scientists or project managers, mentor employees, manage complex and high-volume study work, and perform other related duties as assigned. Work schedule: Monday through Friday, day shift. The application window is October 16, 2026 through October 31, 2026. Pay range: $80,000–$95,000 annually.

Requirements

Bachelor’s degree in Chemistry, Biology, or a related stated discipline.
At least 3–4 years of experience supporting lead scientific projects involving external methods and projects.
At least 2 years of Good Laboratory Practice (GLP) experience.
At least 2 years of Liquid Chromatography Mass Spectrometry experience.
At least 2 years of bioanalytical method development and validation experience.
Excellent communication and interpersonal skills.
Demonstrated ability to prioritize and manage time.
Excellent attention to detail.
Ability to use word processing, database, spreadsheet, and specialized software.

Nice To Haves

Master’s degree in a science field such as Chemistry or Biology, or a related field.
At least 1 year of experience with Watson, Nautilus, and Analyst software.
At least 1 year of Root Cause Analysis experience.
At least 2 years of experience working with regulatory agency guidelines and SOPs.

Responsibilities

Lead and direct scientific work supporting external methods and projects; serve as an applicable scientific director, responsible scientist, coordinating scientist, lead scientist, or principal investigator for non-regulated, GLP-regulated, and GCP-regulated studies.
Ensure client programs meet Labcorp, client, and regulatory requirements and defined drug-development milestones.
Develop and review protocols and sample analysis plans; review methods with method development teams for validation readiness; approve validation methods and review sample analysis methods.
Independently review and approve raw data; identify and document circumstances that may affect study quality or integrity and ensure appropriate corrective action is taken.
Evaluate data and tables for regulatory compliance and review and approve reports for scientific accuracy and completeness.
Ensure on-time delivery of high-quality data and reports; provide technical support and lead troubleshooting and assay problem-solving.
Manage scientific investigations; approve QA project-specific inspections and data archival; evaluate proposals for technical feasibility.
Support scientific papers or posters for publication or presentation at scientific meetings.
Serve as the scientific point of contact for clients; determine project requirements, lead pre-initiation meetings when needed, and participate in client visits as a scientific lead.
Provide scientific direction to study teams; identify scientific issues and scope changes; communicate and monitor scientific expectations with staff and clients.
Proactively identify ways to increase client satisfaction, assist clients with experimental design outside SOPs, and respond to unscheduled deadlines, client needs, and crises while managing other responsibilities.
Promote study quality, collaboration, and a positive impression of Labcorp; provide technical resources and guidance to clients, departments, and less experienced team members.
Lead new employee training and develop training materials and schedules.
Identify process improvement opportunities and participate in improvement initiatives.
Advocate Labcorp’s ethics, vision, and values and foster a high-performance culture.
Participate in projects and tasks beyond lead scientist responsibilities; regularly support other lead scientists or project managers; mentor employees.
Plan, prioritize, and manage workload for large, complex projects and high-volume study work for key clients; take accountability for scientific study conduct and manage time effectively.
Perform other related duties as assigned.