Principal Investigator / Associate Director, In Vivo Pharmacology and Biology
About The Position
Alterome Therapeutics is a clinical-stage biotech company focused on developing treatments for patients with limited options, particularly in oncology. They are seeking a Principal Investigator / Associate Director, In Vivo Pharmacology and Biology to lead preclinical oncology studies. This role involves designing, executing, and interpreting studies to demonstrate the efficacy of their science, including PK/PD studies, dose and regimen strategy, and utilizing various tumor models. The position also includes managing CRO partnerships, translating data into recommendations for program leadership, and building the necessary in vivo infrastructure. The specific title (Principal Investigator or Associate Director) will depend on the candidate's qualifications and experience. The company emphasizes a collaborative, high-trust environment with a focus on accountability, creativity, perseverance, longevity, and compassion.
Requirements
- Ph.D. in Pharmacology, Cancer Biology, or related field + 5 years in vivo pharmacology in biotech/pharma (or MS + 8 years, or BS + 10 years).
- A track record of designing and executing in vivo efficacy and PK/PD studies, ideally in oncology or immuno-oncology.
- Direct experience managing outsourced studies at CROs and working with PDX/CDX models.
- Comfort translating complex data into clear, decision-ready recommendations.
- Excellent communication and presentation skills.
Nice To Haves
- Recent experience working with KRAS-driven cancers and/or MAPK signaling pathway biology.
Responsibilities
- Design and direct in vivo efficacy and PK/PD studies, from dose selection through data interpretation.
- Own CRO relationships: protocol review, study monitoring, troubleshooting, and data quality.
- Partner with DMPK, translational, and clinical teams to turn model data into program strategy.
- Evaluate and onboard new PDX, CDX, and other translationally relevant tumor models.
- Integrate biomarker and translational endpoints into study design.
- Present findings directly to program and executive leadership.
- Build the data systems and standardized workflows that make in vivo pharmacology scale.
- Act as a hands-on individual contributor.
Benefits
- Bonus
- Equity
- Benefits
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
