Principal Clinical Scientist

Natera

8d • Remote

About The Position

We are seeking a Principal Clinical Scientist to lead execution of key components of clinical development for our multi-cancer early detection (MCED) program. This role is central to driving study design, clinical data review, and scientific insights across multiple studies. You will serve as a clinical science lead within cross-functional teams – partnering with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory to advance study execution and shape clinical strategy. This is a high-impact role for someone who can operate independently, manage complexity across studies, and influence decision-making at the study and program level.

Requirements

• Advanced degree (PhD, PharmD, MD, or equivalent; MS/RN with experience considered)
• 8–12 years of experience in clinical research, clinical science, or related field
• Strong experience leading clinical studies and contributing to study design
• Experience with clinical data review and interpretation
• Ability to lead complex clinical studies or multiple workstreams independently
• Strong analytical skills with ability to synthesize complex data into decisions
• Effective influencer across functions and senior stakeholders
• Strong ownership mindset with ability to prioritize across competing demands
• Excellent scientific communication skills
• Ability to operate effectively in a fast-paced, ambiguous environment

Nice To Haves

• Experience in oncology, diagnostics, or early cancer detection
• Experience working across multiple studies or programs
• Track record of scientific publications and conference presentations

Responsibilities

• Lead substantial aspects of MCED clinical studies or multiple studies
• Drive study design, including objectives, endpoints, eligibility criteria, and schedules of assessments
• Author and review protocols, ICFs, CRFs, and study documents
• Contribute meaningfully to clinical development strategy and study-level decision-making
• Contribute to process improvements and development of best practices
• Lead medical and clinical data review to ensure data quality and integrity
• Analyze complex datasets to identify trends, risks, and opportunities
• Translate data into actionable insights that inform study and program decisions
• Partner with safety and medical teams on signal detection and escalation
• Lead cross-functional study teams and coordinate execution across functions
• Collaborate with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory
• Influence decisions and align stakeholders across competing priorities
• Represent Clinical Science in internal and external forums (e.g., investigators, KOLs)
• Oversee enrollment, site performance, and key study metrics across studies
• Identify risks and proactively adjust study-level strategies
• Prioritize activities across studies to ensure quality, timelines, and program impact
• Contribute to forecasting, planning, and milestone delivery
• Lead development of abstracts, presentations, and manuscripts
• Translate clinical and statistical results into clear scientific narratives
• Support internal decision-making and external evidence generation

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents
• Free testing for employees and their immediate families
• Fertility care benefits
• Pregnancy and baby bonding leave
• 401k benefits
• Commuter benefits
• Generous employee referral program

What This Job Offers

• Job Type: Full-time
• Career Level: Principal