Principal Business Manager, Early Clinical Development (ECD)

Genentech • Daly City, CA

7d • $136,100 - $252,700 • Hybrid

About The Position

The Early Clinical Development (ECD) Business Manager acts as a key strategic advisor to the assigned Leadership Team and Senior Leaders within gRED ECD. Reporting directly to the ECD Chief of Staff, this role leads short- and long-term business planning, strategy formulation, resource allocation, budget oversight, and execution across the department. This position requires SSF on-campus presence between 3 to 4 times a week based on business demands.

Requirements

• Bachelor’s degree required
• 5–10 years in business management, cross-functional initiatives, or operations programs (clinical development experience preferred).
• Expertise in strategic planning, project management, business process improvement, and team facilitation.
• Proactive problem solver skilled at challenging standard processes, proposing creative solutions, and adapting to fast-changing demands.
• Strong written, oral, and presentation skills with a proven ability to build transparent, productive cross-functional relationships.
• Demonstrated ability to develop and execute change management and communication strategies across the enterprise.
• Onsite presence on our South San Francisco campus is expected for at least 3 days a week.

Nice To Haves

• project management or process improvement certifications (PMP, Six Sigma, Agile, Change Management) preferred.

Responsibilities

• Fosters team alignment and builds networks across functions, enterprise teams, and external partners to achieve key milestones.
• Drives talent development, engagement programs, departmental workshops, and recognition initiatives to foster professional growth.
• Serves as a thought partner to executive leadership, advising on priorities, providing constructive challenge, and driving short- and long-term enterprise strategy.
• Structures leadership meetings with clear agendas, concise documentation, and rigorous follow-up on action items.
• Oversees annual planning, resource forecasting, budget allocation, and goal setting.
• Balances innovation with guardrails, recommending operational strategies to address evolving enterprise needs.
• Resolves complex business challenges by mobilizing stakeholders and aligning functional goals with broader organizational priorities.
• Ability to work over 8 hours/day or 40 hours/week, including early morning or late-night calls, to meet business demands.
• Capacity to respond promptly to emails and phone calls as business needs arise.
• Ability sitting or standing for extended periods during back-to-back meetings.
• Ability to carry up to 10 lbs of materials and travel between campus buildings for meetings and offsites.
• Ability to travel domestically and internationally as needed.

Benefits

• A discretionary annual bonus may be available based on individual and Company performance.
• This position also qualifies for the benefits detailed at the link provided below.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal