Principal Biologist/Senior Principal Biologist, Immune Aging

Eli Lilly and Company • San Francisco, CA

3d • Onsite

About The Position

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. Lilly is building an exploratory research effort centered on immune aging, with active programs in T cell biology, cellular reprogramming, CAR-T applications, and the immune–stromal interactions that sustain chronic inflammation. We are hiring a Principal Biologist to serve as a hands-on technical driver of this work, executing experiments on programs designed by the project lead, generating decision-grade data, and contributing recognized bench expertise in primary human immune cell biology.

Requirements

• Master’s degree in Immunology, Cell Biology, Molecular Biology, or a closely related discipline, with 3+ years of industry research experience; or a Bachelor’s degree with 5+ years of industry research experience.
• Experience with immunoassays (ELISA, MSD, HTRF), multi-color flow cytometry (staining, acquisition, and analysis in FlowJo), and protein detection methods such as Western blotting.
• Current US work authorization is required.

Nice To Haves

• Working knowledge of cell and molecular biology concepts and a strong grasp of underlying assay principles.
• Hands-on experience with cell lines, whole blood, and isolation and culture of primary human immune cells.
• Demonstrated ability to operate and troubleshoot independently, with consistent, reproducible execution and strong technical communication.
• Experience with cellular and biochemical assays in 96- and 384-well formats.
• Research experience with small molecules, biologics, and/or genetic medicine modalities.
• Experience with lentiviral and retroviral systems.
• Light computational competence for flow data analysis (FlowJo) and basic data wrangling; deep computational expertise is not required.

Responsibilities

• Execute primary human immune cell experiments across multiple projects under the direction of the project lead, including isolation, culture, and functional characterization of T cells and other immune populations.
• Design and run multiparameter flow cytometry and complementary molecular and cellular assays to interrogate target biology, including panel design, FACS sorting, multiplex cytokine quantification, Western blot, qRT-PCR, co-culture systems, and functional readouts of T cell activity and senescence.
• Deliver decision-grade data through rigorous controls and pre-specified analysis plans; troubleshoot independently using evidence-based reasoning; and surface limitations and unexpected findings proactively.
• Communicate results clearly through written summaries, presentation-quality figures, and team scientific reviews, while maintaining disciplined experimental records.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Principal