Principal Bioinformatician
Legend Biotech US•Somerset, NJ
•$146,410 - $192,164•Hybrid
About The Position
Legend Biotech is seeking a Principal Bioinformatician as part of the Early Drug Development team based in Somerset, NJ or Remotely. This role is to support translational strategies across pipeline development programs. He/She will lead computational analyses integrating multi-modality clinical, and biomarker datasets to enable mechanism-of-action understanding, patient stratification, pharmacodynamic assessment, etc. to support translational decision-making.
Requirements
- PhD (5+ years) or MS (8+ years) in Bioinformatics, Computational Biology, Genomics, Systems Biology and related quantitative biological sciences.
- Strong expertise in bioinformatics, statistics with some biological training background, with experience in translational research in oncology, immunology or autoimmune disease.
- Strong experience with: R and/or Python programming, Linux/Unix computing environments, Workflow management systems (e.g., Snakemake, Nextflow, WDL) with Cloud platforms (AWS, GCP, Azure) preferred.
Nice To Haves
- Gene and cell therapy involvement is a plus.
Responsibilities
- Translational Biomarker Analysis with multi-modality and multi-omics assays such as Bulk and Single cell RNA-seq, TCR/BCR-seq, WGS/WES, Amplicon-seq, ATAC-seq, ctDNA/liquid biopsy, Proteomics and cytokine profiling, spatial and multiplex imaging, Flow cytometry/CyTOF.
- Support translational biomarker discovery and validation including identification of pharmacodynamic (PD), predictive, prognostic, and response biomarkers; integrated analyses correlating biomarker data with: Clinical outcomes, PK/PD measurements, Safety for Patient stratification and Mechanism-of-action hypotheses.
- Build and maintain reproducible and scalable bioinformatics pipelines using cloud or high-performance computing environments. Contribute to translational data infrastructure and data governance strategies. Ensure analysis reproducibility, traceability, and documentation compliance.
- Partner closely with Translational scientists, Clinical Development, Research and CMC teams, CROs and collaborators to help translate complex computational findings into biologically meaningful insights.
- Contribute to regulatory documentation required biomarker sections of INDs, IBs, Clinical study reports and Regulatory briefing documents.
- He/she has the authority to make decisions related to methodologies and approaches development processes. He/she can make decisions related to project execution, including timelines, milestones and resource allocation within budget. Higher-level approvals are required for those related to significant technical selection, budget allocations, strategic shifts, or major collaborations that have substantial scientific, financial or long-term implications.
Benefits
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after just three (3) months of employment
- Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
- Flexible spending and health savings accounts
- Life and AD&D insurance
- Short- and long-term disability coverage
- Legal assistance
- Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
- Voluntary commuter benefits
- Family planning and care resources
- Well-being initiatives
- Peer-to-peer recognition programs
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What This Job Offers
Job Type
Full-time
Career Level
Principal
