Principal Bioinformatician
Legend Biotech US•Somerset, NJ
•Remote
About The Position
This role is to support translational strategies across pipeline development programs. He/She will lead computational analyses integrating multi-modality clinical, and biomarker datasets to enable mechanism-of-action understanding, patient stratification, pharmacodynamic assessment, etc. to support translational decision-making.
Requirements
- PhD (5+ years) or MS (8+ years) in Bioinformatics, Computational Biology, Genomics, Systems Biology and related quantitative biological sciences.
- Strong expertise in bioinformatics, statistics with some biological training background, with experience in translational research in oncology, immunology or autoimmune disease.
- Strong experience with: R and/or Python programming, Linux/Unix computing environments, Workflow management systems (e.g., Snakemake, Nextflow, WDL) with Cloud platforms (AWS, GCP, Azure) preferred
Nice To Haves
- Gene and cell therapy involvement is a plus.
Responsibilities
- Translational Biomarker Analysis with multi-modality and multi-omics assays such as Bulk and Single cell RNA-seq, TCR/BCR-seq, WGS/WES, Amplicon-seq, ATAC-seq, ctDNA/liquid biopsy, Proteomics and cytokine profiling, spatial and multiplex imaging, Flow cytometry/CyTOF.
- Support translational biomarker discovery and validation including identification of pharmacodynamic (PD), predictive, prognostic, and response biomarkers; integrated analyses correlating biomarker data with: Clinical outcomes, PK/PD measurements, Safety for Patient stratification and Mechanism-of-action hypotheses.
- Build and maintain reproducible and scalable bioinformatics pipelines using cloud or high-performance computing environments.
- Contribute to translational data infrastructure and data governance strategies.
- Ensure analysis reproducibility, traceability, and documentation compliance.
- Ensure analysis reproducibility, traceability, and documentation compliance.
- Partner closely with Translational scientists, Clinical Development, Research and CMC teams, CROs and collaborators to help translate complex computational findings into biologically meaningful insights.
- Contribute to regulatory documentation required biomarker sections of INDs, IBs, Clinical study reports and Regulatory briefing documents.
- He/she has the authority to make decisions related to methodologies and approaches development processes.
- He/she can make decisions related to project execution, including timelines, milestones and resource allocation within budget.
- Higher-level approvals are required for those related to significant technical selection, budget allocations, strategic shifts, or major collaborations that have substantial scientific, financial or long-term implications.
Benefits
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after just three (3) months of employment
- Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
- Flexible spending and health savings accounts
- Life and AD&D insurance
- Short- and long-term disability coverage
- Legal assistance
- Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
- Voluntary commuter benefits
- Family planning and care resources
- Well-being initiatives
- Peer-to-peer recognition programs
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
Upload and Match Resume
What This Job Offers
Job Type
Full-time
Career Level
Principal
