Principal Associate Scientist, DTD
About The Position
Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a highly skilled and motivated bench scientist to join the Discovery & Translational Development team to support our clinical and pre-clinical programs. The ideal candidate will have a strong scientific background in mammalian cell culture, assay development, and molecular biology. Reporting to the Senior Principal Scientist, Scientific Lead, this is an on-site position based out of Solid’s headquarters in Charlestown, MA.
Requirements
- MS in Biology or related discipline with 5+ years of industry experience or BS with 7+ years of industry experience
- Proficiency with mammalian cell culture, cell line engineering, and/or iPSC differentiation, and experience with transfection or AAV transduction
- Proficient in quantitation of DNA, RNA, and protein expression by ddPCR, qPCR, ProteinSimple Jess, ELISA, and MSD
- Software proficiency including Geneious, SnapGene, NCBI, BLAST, Ensembl, GraphPad Prism, Benchling, and Microsoft Office Suite
- Ability to work independently and collaboratively
- Strong organizational, written, and verbal communication skills
Nice To Haves
- Background in Friedreich’s ataxia and mitochondrial biology is preferred
Responsibilities
- Develop AAV functional potency assays by transfecting, transducing, and/or engineering mammalian cell lines
- Develop molecular assays (ddPCR, ProteinSimple Jess) and cell-based assays to assess expression cassettes and AAV potency
- Develop ELISA and MSD assays to identify novel biomarkers using patient and nonclinical samples
- Support oversight and review or CRO activities
- Maintenance of electronic lab notebook (ELN) documenting experimental procedures, materials, reagents, and data
- Independently analyze experimental data accurately and efficiently, drawing valid conclusions.
- Ensure proper maintenance of laboratory equipment and ensure a safe working environment.
- Participate in projects across different programs, providing expertise where needed.
- Share findings and methodologies with peers to foster a collaborative environment. Provide guidance/mentorship to junior scientists.
- Adapt to shifting priorities and contribute to multiple projects as required.
- Conduct all activities in accordance with regulatory guidelines and company policies.
- Ensure all experimental procedures meet quality standards.
- Maintain accurate and detailed records of all experiments and results.
- Communicate progress and results to scientific leads and team members regularly.
- Participate actively in team meetings, providing updates and insights. Effective communication and interpretation of complex scientific subjects to all audiences.
- Build positive working relationships within the team and across the organization. Apply learnings from the broader organization as they relate to the project team.
Benefits
- Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
- 401(k) program participation with competitive company matched contributions
- Eligibility to participate in Solid’s Employee Stock Purchase Plan
- Mobile phone subsidy for eligible employees
- Tuition Reimbursement
- Vision Coverage
- Life Insurance
- Voluntary Pet Insurance
- Employee Discount Program on Travel, Entertainment, and Services
- Employee Assistance Programs
- Daily Subsidized Lunch Delivery (onsite @ Hood Park)
- Free Onsite Full-Service Gym (onsite @ Hood Park)
- Employee Parking (onsite @ Hood Park)
- 12 Observed Holidays and a winter shut down
- 15-day PTO Policy and an 80-hour rollover YoY
- 40-hour Sick Policy
- 8 Hour Floating Holiday
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What This Job Offers
Job Type
Full-time
Career Level
Senior
