Pre-Clinical Statistician

Eli Lilly and Company • Us, IN

2d • Onsite

About The Position

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. We are seeking a candidate with experience in pre-clinical research, particularly in the oncology space.

Requirements

• Ph.D. in Statistics or Biostatistics
• Experience in oncology research is preferred
• Expertise and experience in study design, mixed models, multivariate analysis, design of experiments, multiplicity control, and analysis of variance
• Proficient in statistical programming languages/software such as R, Python, SAS®, JMP®, etc.
• Demonstrated problem solving ability and critical thinking
• Interpersonal communication skills for effective customer consultation and collaboration
• An established track record of developing and maintaining an area of statistical or collaborative research

Nice To Haves

• Experience with pre-clinical, biomarker, genomics/genetics, or discovery research data and analyses
• Experience manipulating and analyzing large data sets
• Knowledge or education in Biology
• Skills in biological pathway/network analysis
• Skills in predictive modeling and machine learning
• Experience working in High-Performance Computing environment

Responsibilities

• Provides technical leadership and expertise in initiating and carrying out multi-disciplinary or cross functional projects that impact the Lilly Research Laboratory and the Statistical Sciences organization
• Leads the assessment and introduction of new statistical technology and methodology, including both frequentist and Bayesian techniques, to apply to broader practice
• Leads the design and analysis of in-vitro and in-vivo experiments to advance the discovery portfolio, innovative study designs, and statistical analysis plans in collaboration with biologists and other researchers
• Provides consultation for specialized biomarker analyses including genomic analysis of RNA expression data and analysis of other biomarker data (single cell RNA, NGS, protein, imaging) in conjunction with pre-clinical and clinical data
• Establish novel visualizations to explain complex results and interactions
• Provides consulting and statistical direction on priority discovery projects
• Work with Drug Discovery teams to understand statistical needs to improve the quality of candidates and shorten drug development timelines. This will involve understanding the experimental objectives, appropriately specifying the primary and secondary endpoints, setting the sample size using statistical power analysis, determining appropriate statistical methods, and analyzing the data to determine the results.
• Engage in the write up of the results and presentations to Project and Scientific Management
• Understand biological assay development needs and advise biologists on experiments required to validate biological assays for Drug Discovery programs. Experience with design of experiments and applications to high throughput screens will be valuable in this role.
• Find opportunities for Meta-Analysis and other Data Mining techniques, and then conduct them, to identify key results from a series of experiments to identify key conclusions from the gestalt of all experiments in the program and determine appropriate next steps the Project Team should prioritize to optimize progress. This will require knowledge of in-house data repositories, knowledge about publicly available data sources and repositories, and the ability to use appropriate data management tools to build the necessary datasets and then to conduct the analysis
• Develop and provide training courses on statistical methods for biologists, chemists, and other research staff
• Potential leadership and direction of contracted statistical analyst support
• Maintain currency with respect to statistical methodology, maintain proficiency in applying new and varied methods, and to be competent in justifying methods selected
• Influence team members regarding appropriate research methods
• Perform peer-review of work products from other statistical colleagues
• Collaborate with team members to write reports and communicate results
• Assist with, or be responsible for, communicating study results via internal governance, manuscripts, or oral presentations in group settings, as well as for communicating one-on-one with key customers and presenting at scientific meetings
• Respond to regulatory queries and interact with regulators
• Understand disease states, competitive landscapes, and the foundational science in order to enhance the level of patient focus and collaboration and be seen as a strong scientific contributor
• Perform work in full compliance with assigned curriculum(s) and will be responsible for following applicable Corporate, Medical, local, and departmental policies, procedures, processes, and training as well as ensuring legal, regulatory and data protection requirements are met in all activities
• Introduce and apply innovative methodology and tools to solve critical problems
• Merge scientific thinking and business knowledge to identify issues, evaluate options and implement solutions
• Lead projects independently and work effectively across functions.
• Apply technical expertise to influence business decisions

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree