Postdoctoral Scientist - Orth Lab

Howard Hughes Medical Institute • Dallas, TX

7d • Onsite

About The Position

The Orth Laboratory, led by HHMI Investigator Dr. Kim Orth at UT Southwestern Medical Center in Dallas, Texas, investigates the molecular mechanisms by which pathogenic bacteria manipulate host cell signaling and immune responses. The lab's research integrates microbiology, biochemistry, cell biology, structural biology, and animal models to understand host-pathogen interactions at the molecular level — with the goal of gaining novel molecular insight into eukaryotic signaling systems. We are seeking a highly motivated Postdoctoral Scientist to join the Orth Lab at UT Southwestern Medical Center. This is an exciting opportunity to investigate the molecular mechanisms by which bacterial pathogens manipulate host cell signaling and immune responses in a dynamic, interdisciplinary research environment. The successful candidate will work primarily independently on their own research project, developing their scientific program and contributing to the lab's broader mission of understanding host-pathogen interactions at the molecular level.

Requirements

• A PhD in Microbiology, Molecular Biology, Biochemistry, Cell Biology, Immunology, or a related field.
• A strong publication record — multiple first-author or co-first author publications in reputable journals required.
• Hands-on experience in molecular biology, microbiology, biochemistry, cell biology, or related techniques.
• Ability to independently design and execute experiments without reliance on technicians.
• Excellent written and verbal communication skills and the ability to work collaboratively.

Nice To Haves

• Experience in structural biology, host-pathogen interactions, or cell signaling pathways.
• Familiarity with animal models used in infectious disease or immunology research.

Responsibilities

• Independently design and execute experiments investigating molecular mechanisms of bacterial pathogenesis and host cell signaling.
• Conduct research integrating microbiology, biochemistry, cell biology, and structural biology approaches.
• Perform tissue culture, invasion studies, structural work, and cellular pathway analyses.
• Analyze, interpret, and present experimental data in lab meetings, seminars, and scientific conferences.
• Prepare and contribute to peer-reviewed manuscripts and publications.
• Collaborate actively with other lab members, postdocs, and members of the broader research community.

Benefits

• Comprehensive HHMI health and wellness benefits.
• Exceptional health benefits.
• Retirement plans.
• Time off.
• A range of recognition and wellness programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree