UNIV - Post Doctoral Scholar - Exempt - Department of Neuroscience

Medical University of South Carolina • Charleston, SC

7d

About The Position

The Song Laboratory in the Department of Neuroscience and Hollings Cancer Center at the Medical University of South Carolina seeks a highly motivated Postdoctoral Research Scholar to investigate molecular mechanisms underlying glioma progression, therapeutic resistance, and tumor-immune interactions. The lab studies RNA alternative splicing, functional genomics, tumor metabolism, and cancer immunology to identify therapeutic vulnerabilities and develop treatments for brain tumors. Research may include exon-centric CRISPR screening for functional splicing dependencies; alternative-splicing regulation of sphingolipid metabolism and therapy resistance; therapeutic targeting of RNA splicing factors; and iPSC-derived microglia-based immunotherapy.

The role integrates molecular and cellular biology, CRISPR technologies, transcriptomics, iPSC models, patient-derived glioma models, and preclinical animal models. The scholar may develop independent research projects, publish findings, and participate in collaborative research and grant applications. Duties include designing and conducting experiments; developing and optimizing methods; collecting, analyzing, and interpreting data; preparing manuscripts and presentations; contributing to grant applications; collaborating with investigators; and potentially mentoring junior laboratory personnel. The position also supports laboratory protocols and compliance with laboratory safety, animal research, and research integrity requirements.

Requirements

• Ph.D., M.D., or equivalent degree.
• In-depth knowledge of cancer biology, molecular biology, immunology, or a related biomedical research discipline.

Responsibilities

• Design, develop, and conduct experiments investigating glioma biology, RNA alternative splicing, tumor metabolism, and tumor-immune interactions.
• Apply molecular and cellular biology techniques, CRISPR-based gene editing and functional screening, patient-derived glioma cell models, and iPSC-derived microglia systems.
• Develop and optimize experimental approaches to investigate molecular mechanisms and evaluate potential therapeutic strategies.
• Collect, organize, analyze, and interpret experimental data using molecular, cellular, genomic, and imaging-based approaches.
• Perform or participate in transcriptomic and functional genomic analyses.
• Maintain accurate experimental records, evaluate findings, and troubleshoot technical challenges.
• Prepare scientific manuscripts, abstracts, presentations, and research reports.
• Contribute to grant applications and new research proposals.
• Collaborate with investigators in neuroscience, cancer biology, immunology, and translational medicine.
• Assist in training and mentoring junior laboratory members and support development of laboratory protocols.
• Ensure compliance with institutional laboratory safety, animal research, and research integrity requirements.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree