Postdoctoral Research Fellow

Mass General Brigham • Boston, MA

1d • Hybrid

About The Position

The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD), a rare neurodegenerative disease. This project aims to evaluate the efficacy of gene editing approaches and small-molecule splicing modulators in a mouse model of FD. The successful candidate will lead in vivo studies and apply molecular, cellular, and genomic approaches to assess therapeutic outcomes. We are seeking a creative, independent, and collaborative scientist with a strong background in molecular neuroscience, gene editing, RNA biology, or neurogenetics. Experience working with mouse models, including behavioral assays and molecular analysis of tissues, is highly desirable. This is a unique opportunity to work at the interface of basic science and translational medicine within a collaborative and highly supportive environment. Our lab is part of the MGH/Harvard/Broad Institute ecosystem, providing access to state-of-the-art resources and a vibrant scientific community.

Requirements

• Doctoral degree
• Molecular biology techniques including DNA, RNA, and protein isolation and manipulation (RT-PCR, qRT-PCR, western blotting)
• Good understanding of genetic methodologies, with experience in cloning, CRISPR/Cas genetic editing techniques, genomic sequencing
• Some level of cell culture experience, including cell lines generation, transfection/transduction, selection, propagation, preservation, and phenotypic characterization
• Some experience with microscopy imaging and immuno-cytochemistry (IHC) techniques
• Histological and immune-histochemical techniques.
• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent English verbal and written communication skills
• Able to work both independently and in a team

Nice To Haves

• Ph.D. in neuroscience, molecular biology, genetics, or a related field.
• Prior experience with rodent models, gene editing, or RNA splicing is strongly preferred.

Responsibilities

• Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.
• Perform downstream analyses, including RNA/protein quantification, splicing analysis, and histological assessments.
• Lead the development and optimization of therapeutic delivery and molecular assays.
• Collaborate with internal and external researchers and contribute to mentorship of junior lab members.
• Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree