The Opferman Laboratory at St. Jude Children’s Research Hospital is seeking a highly motivated and creative postdoctoral fellow to study how mitochondrial biology and the BCL-2 family protein MCL-1 govern normal hematopoiesis, stem cell maintenance, lineage commitment, and cellular stress responses, and how these pathways become dysregulated in acute myeloid leukemia (AML) and other hematologic malignancies. The laboratory integrates molecular and cellular biology, mouse genetics, biochemistry, cancer biology, metabolism, epigenetics, genomics, proteomics, and advanced imaging to investigate fundamental questions in stem cell and cancer biology. Current projects examine the non-apoptotic functions of MCL-1, mitochondrial metabolism and quality control, mechanisms regulating hematopoietic stem cell self-renewal and differentiation, and metabolic and epigenetic pathways that drive leukemic stem cell maintenance and therapeutic resistance. The research aims to define fundamental biological mechanisms that may support the development of more effective therapies for hematologic diseases. St. Jude is a collaborative multidisciplinary research institution focused on pediatric cancer and other catastrophic childhood diseases. Postdoctoral trainees have access to shared research resources and facilities, professional and career-development programs, a professional development allowance, competitive compensation, comprehensive benefits, relocation assistance, and a supportive postdoctoral community.
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Job Type
Full-time
Career Level
Entry Level
Education Level
No Education Listed