Postdoctoral Research Associate - Developmental Neurobiology

St. Jude Children's Research Hospital • Memphis, TN

3d • Onsite

About The Position

A postdoctoral position is available in the laboratory of Dr. Young-Goo Han in the Department of Developmental Neurobiology/Neurobiology and Brain Tumor Program at St. Jude Children’s Research Hospital. The Han laboratory studies the biology of primary cilia and how cilia-dependent signaling regulates cell behavior in normal development and disease, with particular emphasis on brain development, brain tumors, neurodevelopmental disorders, and neurodegenerative diseases. The Han laboratory has made important contributions to understanding the roles of primary cilia and Hedgehog signaling in neural stem cell formation, cerebellar development, medulloblastoma, neocortical growth and folding, and cilia-dependent regulation of translation and the cell cycle. Applicants who are interested in fundamental mechanisms by which primary cilia or mitochondria control cellular homeostasis and signaling are encouraged to apply. We use a broad range of approaches, including human pluripotent stem cells, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, epigenomics, and proteomics, as well as a unique mouse model in which neural progenitors acquire key features of human neural progenitors, driving expansion and folding of the normally small, smooth mouse cortex.

Requirements

• Ph.D., M.D., or equivalent degree.
• Strong background in cell biology, molecular biology, developmental biology, neuroscience, cancer biology, neurodegeneration, or a related field.
• Highly motivated candidates with strong communication skills.
• A record of scientific productivity.

Nice To Haves

• Experience in primary cilia biology.
• Experience in mitochondrial homeostasis.
• Experience in mouse genetics.
• Experience in imaging.
• Experience in biochemistry.
• Experience in genomics.
• Experience in stem/progenitor cell biology.
• Experience in disease models.

Responsibilities

• Conduct research in primary cilia biology and its role in development and disease.
• Investigate cilia-dependent signaling in brain development, brain tumors, neurodevelopmental disorders, and neurodegenerative diseases.
• Utilize a range of approaches including human pluripotent stem cells, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, epigenomics, and proteomics.
• Work with a unique mouse model to study neural progenitor behavior.
• Pursue mechanistic and conceptually innovative projects at the interface of cell biology, development, and disease.

Benefits

• Outstanding and highly collaborative research environment.
• Exceptional core facilities.
• Strong support for postdoctoral training and career development.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree