Postdoctoral Research Associate -Structural Biology - Mittag Lab

St. Jude Children's Research Hospital•Memphis, TN

3d•Onsite

About The Position

A postdoctoral research associate position is available in the lab of Tanja Mittag in the Department of Structural Biology. The Mittag laboratory invites applications for a Postdoctoral Research Associate Position to work on the biophysics of sequence–structure–function relationships of intrinsically disordered protein regions (IDRs). IDRs use different types of sequence-encoded grammars, and these are often tied to their subcellular localization and the biological processes they are involved in. We have extensively characterized how the molecular grammar of prion-like low-complexity domains encode conformational preferences and give rise to condensates with specific emergent properties (e.g., Martin et al. Science 2020, Bremer et al. Nat Chem 2022, Farag et al. Nat Commun 2023; Alshareedah et al. Nat Physics 2024; Posey et al JACS 2024). In this project, we will define how IDRs with different types of molecular grammars encode different emergent properties.

Requirements

Ph.D. in biophysics or a related discipline.
Academic record of excellence.
Strong interest in the growing field of biomolecular condensates.
Experience with molecular biology, protein biochemistry and quantitative biophysical techniques is required.

Responsibilities

Help shape the direction of the research.
Use in vitro biophysical and biochemical studies to characterize the emergent properties of condensates formed by IDRs with different molecular grammars.
Interface with trainees and staff scientists in the Mittag lab, and with collaborators in a highly collaborative, interdisciplinary environment that will support their career development.