Postdoctoral Fellow-MSH-30035-400
About The Position
We will investigate the role of Sirt7, a histone deacetylase, in D1-type medium spiny neurons (D1-MSNs), focusing on how it shapes synaptic plasticity and modulates resilience to compulsive alcohol drinking. Our central hypothesis is that epigenetic changes in D1-MSNs of the dorsomedial striatum, driven primarily by histone acetylation and modulated by Sirt7, promote transcriptional and synaptic adaptations that jointly confer resilience to compulsive-like drinking. The rationale for this project is grounded in compelling preliminary data suggesting that transcriptional changes in the histone acetylation process, particularly those regulated by Sirt7, are associated with reduced compulsive-like drinking in mice through the transcriptional control of synaptic pathways. The goal of this research is to identify mechanisms that promote resilience to compulsive alcohol drinking, a clinically relevant phenotype of AUD characterized by continued drinking despite adverse consequences.
Requirements
- PhD in Biological Science
- At least 5 years of experience working with laboratory mice, including mouse handling and behavioral experiments.
Responsibilities
- Conducting alcohol-related behavioral experiments, including operant self-administration and other drinking paradigms
- Maintaining and managing mouse colonies
- Performing stereotaxic surgeries and related experimental procedures
- Monitoring animals throughout behavioral studies
- Collecting brain tissue for downstream molecular and cellular analyses
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
