Postdoctoral Fellow

City of Hope • Duarte, CA

2d • Onsite

About The Position

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Fellowship position is immediately available in the laboratory of Dr. Christine Brown. One major area of research focus is the development of CAR T cell therapy for the treatment of glioblastoma (GBM), the most common and aggressive type of adult primary brain tumor. Ongoing projects include addressing the challenge of tumor heterogeneity to reduce the potential of tumor antigen escape, overcoming the suppressive tumor micro-environment to improve CAR T cell function, monitoring tumor trafficking, optimizing CAR T cell route of delivery, and improving CAR T cell manufacturing. Other areas of interest include understanding the interplay between CAR T cells and the host immune micro-environment, functionalizing CARs using the meditope cyclic peptide technology and CRISPR/Cas9 modification of CAR T cells for improved functionality.

Requirements

• Ph.D., M.D., or equivalent doctoral degree in life sciences or a related field.

Responsibilities

• Develop CAR T cell therapy for the treatment of glioblastoma (GBM).
• Address tumor heterogeneity to reduce tumor antigen escape.
• Overcome the suppressive tumor micro-environment to improve CAR T cell function.
• Monitor tumor trafficking.
• Optimize CAR T cell route of delivery.
• Improve CAR T cell manufacturing.
• Understand the interplay between CAR T cells and the host immune micro-environment.
• Functionalize CARs using meditope cyclic peptide technology.
• Perform CRISPR/Cas9 modification of CAR T cells for improved functionality.

Benefits

• Comprehensive Benefits

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree